Is ibuprofen superior to indomethacin for patent ductus arteriosus in Japanese preterm infants?
| Autor: | Ayumi Oshima, Fumihiko Namba, Masayo Kanai, Satoshi Masutani, Akio Ishiguro, Shun Matsumura, Kazuhiko Kabe |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Indomethacin Ibuprofen 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Japan Oliguria 030225 pediatrics Internal medicine Ductus arteriosus medicine Humans Adverse effect Ductus Arteriosus Patent Creatinine business.industry Acute kidney injury Infant Newborn Gestational age Infant biochemical phenomena metabolism and nutrition Jaundice Infant Low Birth Weight medicine.disease medicine.anatomical_structure chemistry Pediatrics Perinatology and Child Health medicine.symptom business Infant Premature medicine.drug |
| Zdroj: | Pediatrics international : official journal of the Japan Pediatric SocietyReferences. 63(8) |
| ISSN: | 1442-200X |
| Popis: | Many clinical trials have indicated that ibuprofen (IBU) has similar effects to indomethacin (IND) on the closure of patent ductus arteriosus (PDA) with fewer adverse effects. Owing to the scarce evidence on IBU use in Japan because of its recent approval we performed this observational study to compare the efficacy and safety of IBU with the efficiency and safety of IND.We included infants (gestational age30 weeks) with hemodynamically significant PDA under a prophylactic IND protocol for intraventricular hemorrhage who were treated with either IND (n = 30) or IBU (n = 30). We compared a PDA closing effect, changes in ultrasonography findings, and adverse effects between the groups.There was no significant difference in the rates of PDA closure in the first treatment course (IND vs IBU: 46.7% vs 50.0%, P = 0.796) and surgical closure (IND vs IBU: 20.0% vs 20.0%, P = 1.000) between the groups. Both groups showed significant oliguria (IND vs IBU: 30.0% vs 23.3%, P = 0.559) and increased serum creatinine levels after treatment. However, an increase in serum creatinine level by0.3 mg/dL, a criterion for acute kidney injury, was less frequent in the IBU group (35.7%) compared with that in the IND group (84.2%, P = 0.004). There were no significant differences in echocardiographic changes and jaundice and hypoglycemia incidence rates between the groups.Except for an increase in serum creatinine levels by0.3 mg/dL, which was less frequent with IBU, IBU had similar efficacy and safety as IND for preterm PDA. Ibuprofen and IND should be cautiously administered. |
| Databáze: | OpenAIRE |
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