Overexpression of UDP-Glucose 4-Epimerase Is Associated with Differentiation Grade of Gastric Cancer

Autor: Michael Williams Leal Quirino, Antônio Felix da Silva Filho, Ivan da Rocha Pitta, Amanda P. B. Albuquerque, Moacyr Jesus Barreto de Melo Rêgo, Maira Galdino da Rocha Pitta, Mário S. de Souza Albuquerque, Antonio R. Lucena-Araujo, Mário Rino Martins, Maria de Fátima Deodato de Souza, Marina Ferraz Cordeiro
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
UDP-glucose 4-epimerase
Cellular differentiation
Clinical Biochemistry
UDPglucose 4-Epimerase
0302 clinical medicine
Medicine
Aged
80 and over
lcsh:R5-920
biology
Cell Differentiation
General Medicine
Middle Aged
Combined Modality Therapy
030220 oncology & carcinogenesis
Lymphatic Metastasis
Biomarker (medicine)
Immunohistochemistry
Female
lcsh:Medicine (General)
Lipid glycosylation
psychological phenomena and processes
Research Article
Adult
Article Subject
education
Adenocarcinoma
behavioral disciplines and activities
03 medical and health sciences
Stomach Neoplasms
Glycosyltransferase
Genetics
Biomarkers
Tumor
Humans
Molecular Biology
Aged
Messenger RNA
business.industry
Biochemistry (medical)
Cancer
medicine.disease
carbohydrates (lipids)
030104 developmental biology
Cancer research
biology.protein
Neoplasm Grading
Neoplasm Recurrence
Local
business
Follow-Up Studies
Zdroj: Disease Markers
Disease Markers, Vol 2019 (2019)
ISSN: 1875-8630
Popis: The UDP-glucose 4-epimerase (GALE) is a glycosyltransferase, which acts on protein and lipid glycosylation in normal and neoplastic cells. This study is aimed at investigating the differential tissue expression of GALE and its possible association with clinical-pathological parameters and the outcome of gastric adenocarcinoma patients. Seventy-one patients were evaluated in relation to GALE expression by immunohistochemistry. Our results showed that 48 (67.6%) patients were GALE positive and 23 (32.4%) negative. Positive staining was present on well-differentiated and moderate-differentiated histological grade of gastric adenocarcinomas (p<0.0001). There was no significant association with outcome parameters (p>0.05). Besides that, our results corroborated with the validation cohort analysis, where the expression of GALE mRNA was also associated with the histological grade (p<0.001). These results suggest a possible use of this enzyme as a biomarker for well and moderately differentiated tumors.
Databáze: OpenAIRE
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