Sensitive silica‐alumina modified capacitive non‐Faradaic glucose sensor for gestational diabetes
| Autor: | Yuanhuan Xiong, Lizhen Chen, Wenyang Xie, Yao Luo, Bing Fu, Xiaolan Ding, Subash C. B. Gopinath |
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| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
Biomedical Engineering Bioengineering Biosensing Techniques 01 natural sciences Applied Microbiology and Biotechnology Capacitance Glucose Oxidase 03 medical and health sciences chemistry.chemical_compound Pregnancy 010608 biotechnology Drug Discovery Aluminum Oxide medicine Humans Glucose oxidase Amines 030304 developmental biology Detection limit 0303 health sciences Chromatography biology Process Chemistry and Technology Fructose General Medicine Enzymes Immobilized Silicon Dioxide medicine.disease Gestational diabetes Diabetes Gestational Glucose chemistry Linear range Galactose biology.protein Molecular Medicine Female Biosensor Biotechnology |
| Zdroj: | Biotechnology and Applied Biochemistry. 69:840-847 |
| ISSN: | 1470-8744 0885-4513 |
| DOI: | 10.1002/bab.2155 |
| Popis: | A highly sensitive silica-alumina (Si-Al)-modified capacitive non-Faradaic glucose biosensor was introduced to monitor gestational diabetes. Glucose oxidase (GOx) was attached to the Si-Al electrode surface as the probe through amine-modification followed by glutaraldehyde premixed GOx as aldehyde-amine chemistry. This Si-Al (∼50 nm) modified electrode surface has increased the current flow upon binding of GOx with glucose. Capacitance values were increased by increasing the glucose concentrations. A mean capacitance value was plotted and the detection limit was found as 0.03 mg/mL with the regression coefficient value, R² = 0.9782 [y = 0.8391x + 1.338] on the linear range between 0.03 and 1 mg/mL. Further, a biofouling experiment with fructose and galactose did not increase the capacitance, indicating the specific glucose detection. This Si-Al-modified capacitance sensor detects a lower level of glucose presence and helps in monitoring gestational diabetes. |
| Databáze: | OpenAIRE |
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