Prevalence and risk factors of sonographically detected non alcoholic fatty liver disease in a screening centre in Klang Valley, Malaysia: an observational cross-sectional study
| Autor: | Ramlah Mohamad Ibrahim, Sarah Qahtan Mohammed Salih, Rozi Mahmud, Abdul Sattar Arif Khammas, Hayati Kadir, Hasyma Abu Hassan, Nurul Nadiah Mohamad Nasir |
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| Rok vydání: | 2019 |
| Předmět: |
nonalcoholic fatty liver disease
medicine.medical_specialty Cross-sectional study Population General Biochemistry Genetics and Molecular Biology Liver disorder 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus Nonalcoholic fatty liver disease risk factors Medicine 030212 general & internal medicine education sonography education.field_of_study business.industry Hypertriglyceridemia Fatty liver Malaysia nutritional and metabolic diseases Anthropometry medicine.disease Original Article business 030217 neurology & neurosurgery |
| Zdroj: | Porto Biomedical Journal |
| ISSN: | 2444-8664 |
| DOI: | 10.1016/j.pbj.0000000000000031 |
| Popis: | Objectives: Nonalcoholic fatty liver disease (NAFLD) is a very common liver disorder in Western countries. As of late, it has been found to be prevalent in Asia as well. It is a benign disease unless it develops into necroinflammation and fibrosis. This study was proposed to determine the prevalence and risk factors of sonography-detected NAFLD among Malaysian adults in Klang Valley, West Malaysia. Study design: An observational cross-sectional study. Methods: The participants were aged between 45 and 75 years who participated in a screening program at the Golden Horses Health Sanctuary in Klang Valley. Lipid profile and anthropometric measurements were collected from the subjects’ medical records. Ultrasound machine and a structured self-administered questionnaire were used as instruments for recruiting data from the subjects. The subjects who consumed alcohol (>140 g/wk for men and >70 g/wk for females), had hepatitis B or C viruses, liver insults, and surgery, and taken lipid-lowering medications were excluded from the study. Results: A total of 628 subjects were analyzed, and 235 (37.4%) subjects were diagnosed with definite NAFLD. They comprised 518 (82.5%) Chinese, 92 (14.6%) Malays, and 18 (2.9%) Indians. Peak prevalence of NAFLD was found in 53 to 60 years age group. The higher prevalence of NAFLD was among men (48.3%) than women (27.3%) and among Indians (61.1%) and Malays (51.1%) than among Chinese (34.2%). NAFLD has been found to be strongly correlated with male sex, high body mass index (≥23.0 kg/m2), hypertriglyceridemia, low high-density lipoprotein cholesterol, diabetes mellitus, and hypertension. Conclusion: NAFLD is quite common among adults in Malaysian urban population. The prevalence of NAFLD was inordinately high among the 53 to 60 years age group, male sex, Indians, and Malays (as compared with Chinese). Age >60 years, male sex, high body mass index (≥23.0 kg/m2), hypertriglyceridemia, and diabetes mellitus were proven to be risk predictors for NAFLD. |
| Databáze: | OpenAIRE |
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