Antifungal and Antiplasmodial Activity of Isolated Compounds from Handroanthus serratifolius (Vahl) S. Grose Sawdusts

Autor:	Claudete Catanhede do Nascimento, Brenna Marceliane de Melo Marcelino, Valter Ferreira de Andrade-Neto, Antonio G. Ferreira, Maria da Paz Lima, Loretta Ennes Sabóia de Melo, Kátia Santana Cruz, Pedro Igor Lima Soares, João Vicente Braga de Souza
Rok vydání:	2019
Předmět:	Cryptococcus neoformans Antifungal Traditional medicine biology medicine.drug_class Genus medicine Plasmodium falciparum biology.organism_classification Cycloolivil Tabebuia serratifolia
Zdroj:	Repositório Institucional do INPA Instituto Nacional de Pesquisas da Amazônia (INPA) instacron:INPA
ISSN:	2456-1908 2349-6495
DOI:	10.22161/ijaers.69.32
Popis:	Handroanthus serratifolius (Vahl) S. Grose [Tabebuia serratifolia (Vahl) G. Nicholson] popularly known in Brazil “ipe-amarelo" is a woody species with potential of sustainable use belonging to a genus known for being as a promising naphthoquinones source which has aroused interest in search for new biological activities. In this paper, the methanolic extract fractionation from H. serratifolius sawdust using different chromatogramphic techniques yielded naphthoquinones dehydro-α-lapachone, dehydro-iso-α-lapachone and α-lapachone, along with lignans paulownin and cycloolivil. The three naphthoquinones presented antiplasmodial activity against Plasmodium falciparum where the dehydro-iso-α-lapachone was more active (IC50 of 7.53 μg/mL). This same compound also exhibited significant antifungal activity against Cryptococcus neoformans.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405becf213f51ec3ccd0221a7dc63964 https://doi.org/10.22161/ijaers.69.32 Zobrazit plný text záznamu