A Study of the Defects in the Blood Coagulation Mechanisms in Polycythemia Vera
| Autor: | Ulutin On, Shirley A. Johnson, Caldwell Mj, Joseph P. Abraham |
|---|---|
| Rok vydání: | 1961 |
| Předmět: |
medicine.medical_specialty
business.industry General Medicine Clot retraction Electrical devices medicine.disease Clot formation Polycythemia vera Coagulation hemic and lymphatic diseases Internal medicine Hemorrhagic complication Hemostasis medicine Cardiology Humans Platelet business Blood Coagulation Polycythemia Vera |
| Zdroj: | American Journal of Clinical Pathology. 36:7-15 |
| ISSN: | 1943-7722 0002-9173 |
| DOI: | 10.1093/ajcp/36.1.7 |
| Popis: | Although the hemorrhagic complications of polycythemia vera are well known, there is a lack of uniform opinion regarding the nature of the hemostatic defect. Physical distention of the vascular bed is a plausible cause of bleeding in uncontrolled polycythemia. In isolated instances, fibrinolytic activity has been noted in polycythemic patients. Aberrant behavior of the polycythemic clot, regularly noted in vitro, may also contribute to faulty hemostasis. In addition, equivocal defects in the coagulation process have been reported sporadically. In 1949 Rosenthal studied a group of 39 cases of polycythemia vera, and observed an increased rate of clot retraction and the fall-out phenomenon in 35 per cent of the patients. He measured clot retraction with an electrical device. Rosenthal attributed the poor clot formation to the high platelet counts and postulated that retraction took place so rapidly that the red cells, instead of adhering to the platelet-fibrin mesh, were forced out of the clot. Henstell and co-workers in 195.1, made similar observations which involved measuring the electrolytic resistance of the blood as clotting |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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