TAM and TIM receptors mRNA expression in Zika virus infected placentas

Autor:	Guilherme M. Nobrega, Ana Paula Samogim, Pierina L. Parise, Emanuella M. Venceslau, José Paulo S. Guida, Rodolfo R. Japecanga, Mariene R. Amorim, Daniel A. Toledo-Teixeira, Julia Forato, Sílvio R. Consonni, Maria Laura Costa, José Luiz Proenca-Modena, Eliana Amaral, Helaine Maria Besteti Pires Mayer-Milanez, Carolina C. Ribeiro-do-Valle, Roseli Calil, João Renato Bennini Junior, Giuliane Jesus Lajos, Albina Altemani, Maria Luiza Moretti, Mariangela Ribeiro Resende, Márcia Teixeira Garcia, Rodrigo Nogueira Angerami, Marcos Tadeu Nolasco da Silva, Ana Carolina Coan, Maria Francisca Colella-Santos, Andrea Paula Bruno von Zuben, André Ricardo Ribas Freitas, Marco Aurélio Ramirez Vinolo, Rodrigo Ramos Catharino, Fábio Trindade Maranhão Costa, Clarice Weis Arns, Aline Vieira, Gabriela Fabiano de Souza, Karina Bispo dos Santos, Mariene Ribeiro Amorim, Matheus Cavalheiro Martini, Stéfanie Primon Muraro
Rok vydání:	2020
Předmět:	0301 basic medicine Mrna expression Placenta Zika virus Interferon Lambda 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Pregnancy Proto-Oncogene Proteins medicine Humans Hepatitis A Virus Cellular Receptor 1 Pregnancy Complications Infectious Receptor Messenger RNA 030219 obstetrics & reproductive medicine biology Zika Virus Infection Obstetrics and Gynecology Receptor Protein-Tyrosine Kinases Zika Virus biology.organism_classification medicine.disease Virology Axl Receptor Tyrosine Kinase 030104 developmental biology medicine.anatomical_structure Reproductive Medicine Case-Control Studies Host-Pathogen Interactions Interferon Type I Female Interferons Developmental Biology TYRO3
Zdroj:	Placenta. 101
ISSN:	1532-3102
Popis:	To investigate the role of TYRO3, AXL and TIM1 receptors in the Zika virus (ZIKV) cycle, we determined their mRNA expression in different placental sites of ZIKV infected tissue during pregnancy. Unexpectedly, the ZIKV infection was not related with mRNA upregulation of these receptors or changes in expression of type I and III interferons in different placental sites. Instead, a decrease of TYRO3 mRNA expression was observed in positive sites of ZIKV positive placentas in comparison to negative sites. The basis of this downregulation can help to understand how ZIKV persists in placental tissue during pregnancy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405a1664b8adf3c774310263a3ba6f84 https://pubmed.ncbi.nlm.nih.gov/33011564 Zobrazit plný text záznamu Full Text from ScienceDirect