Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4⁺ T cells
| Autor: | Kenneth M. Murphy, Ansuman T. Satpathy, Todd C. Metzger, Arthur Weiss, Kristin V. Tarbell, Byron B. Au-Yeung, James M. Gardner, Anna K. Krawisz, Kellsey Johannes, Jeffrey D. Price, Wen Lu, Eileen J. McMahon, Mark S. Anderson |
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| Rok vydání: | 2013 |
| Předmět: |
CD4-Positive T-Lymphocytes
Adoptive cell transfer Autoimmunity Immune tolerance Mice 0302 clinical medicine CD80 Mice Inbred NOD Immunology and Allergy 2.1 Biological and endogenous factors CD86 CD45 Aetiology 0303 health sciences Antigen Presentation Autoimmune regulator Epithelial Cell Adhesion Molecule Adoptive Transfer 3. Good health Cell biology Infectious Diseases Self Tolerance B7-1 Antigen 1.1 Normal biological development and functioning Antigen presentation Immunology Antigen-Presenting Cells Bone Marrow Cells Biology Autoimmune Disease 03 medical and health sciences Antigen Antigens Neoplasm Underpinning research Animals Antigens Antigen-presenting cell 030304 developmental biology Inflammatory and immune system Histocompatibility Antigens Class II Inbred NOD Neoplasm Leukocyte Common Antigens B7-2 Antigen Cell Adhesion Molecules 030215 immunology Transcription Factors |
| Zdroj: | Immunity, vol 39, iss 3 |
| Popis: | The autoimmune regulator (Aire) is essential for prevention of autoimmunity; its role is best understood in the thymus, where it promotes self-tolerance through tissue-specific antigen (TSA) expression. Recently, extrathymic Aire-expressing cells (eTACs) have been described in murine secondary lymphoid organs, but the identity of such cells and their role in immune tolerance remains unclear. Here we have shown that eTACs are a discrete major histocompatibility complex class II (MHC II)(hi), CD80(lo), CD86(lo), epithelial cell adhesion molecule (EpCAM)(hi), CD45(lo) bone marrow-derived peripheral antigen-presenting cell (APC) population. We also have demonstrated that eTACs can functionally inactivate CD4⁺ T cells through a mechanism that does not require regulatory T cells (Treg) and is resistant to innate inflammatory stimuli. Together, these findings further define eTACs as a distinct tolerogenic cell population in secondary lymphoid organs. |
| Databáze: | OpenAIRE |
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