Iodised rapeseed oil for eradication of severe endemic goitre

Autor:	F Bordet, L Jung, AM Goncalves, G Férard, L Dechoux, Y Ingenbleek
Rok vydání:	1997
Předmět:	Adult Male Thyroid Hormones medicine.medical_specialty Rapeseed Chad chemistry.chemical_element Brassica Iodine Brassiodol Endemic goitre Fatty Acids Monounsaturated Toxicology Internal medicine medicine Humans Plant Oils Urinary output business.industry Fatty Acids Iodized Oil General Medicine medicine.disease Iodine deficiency Endocrinology chemistry Lipiodol Female Rapeseed Oil Iodised oil business Goiter Endemic medicine.drug
Zdroj:	The Lancet. 350:1542-1545
ISSN:	0140-6736
DOI:	10.1016/s0140-6736(97)02427-6
Popis:	Summary Iodised oil is traditionally based on the fatty acids (FAs) of the poppyseed, an expensive commodity. An equipotent but cheaper vehicle would be welcome, lodination of rapeseed oil yields a product (Brassiodol) with a total iodine content of 376 mg/mL. Brassiodol has been compared with the poppyseed-based Lipiodol in two villages in Chad in the west African goitre belt. A 2 mL dose of Brassiodol is followed by urinary spillover of half the ingested iodine. The other half undergoes tissue sequestration and slow release, allowing protection against iodine deficiency for 9 months and regression of stage l/ll goitre for longer than was achieved with Lipiodol. The prolonged protection offered by Brassiodol can be attributed to its unique lipid profile. The urinary output argues that 1 mL should not be exceeded, and at that dose the cost would be only 20 US cents per person per year.
Databáze:	OpenAIRE
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