mascRNA promotes macrophage apoptosis, inhibits osteoclast differentiation and attenuates disease progression in a murine model of arthritis

Autor:	Xuxu Wang, Tao Sun, Xiaohua Mao
Rok vydání:	2022
Předmět:	Inflammation Macrophages Biophysics Osteoclasts Apoptosis Cell Biology Biochemistry Arthritis Experimental Arthritis Rheumatoid Disease Models Animal Mice Disease Progression Animals Molecular Biology
Zdroj:	Biochemical and biophysical research communications. 611
ISSN:	1090-2104
Popis:	Macrophages play a crucial role in the pathogenesis of rheumatoid arthritis (RA) and have been considered as a therapeutic target of this disease. Here we show that mascRNA, a tRNA-like cytoplasmic small noncoding RNA, promoted RIPK1-dependent apoptosis (RDA) in RAW267.4 macrophages in response to the TAK1 inhibitor 5Z-7-oxozeaenol (5Z-7) alone as well as in combination with TNF. Moreover, mascRNA suppressed RANKL-induced expression of osteoclast marker genes and attenuated RANKL signaling. Using a murine model of collagen-induced arthritis (CIA), we demonstrated that mascRNA, administered either alone or in combination with 5Z-7, alleviated joint inflammation in CIA mice. Thus, mascRNA might be a promising agent for the treatment of RA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4054f087f79b3f6e1b24e381dbee512d https://pubmed.ncbi.nlm.nih.gov/35489201 Zobrazit plný text záznamu Full Text from ScienceDirect