Pembrolizumab-induced Sarcoid-like Reactions during Treatment of Metastatic Melanoma
| Autor: | Alexandra R Lewis, Ruth E. Board, Michael J Dobson, Laxminarayan D Gudur, Sophie C Cheshire |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Biopsy Prednisolone Lymphadenopathy Disease Pembrolizumab Antibodies Monoclonal Humanized 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Antineoplastic Agents Immunological hemic and lymphatic diseases Positron Emission Tomography Computed Tomography medicine Humans Radiology Nuclear Medicine and imaging Glucocorticoids Melanoma Bilateral hilar lymphadenopathy medicine.diagnostic_test business.industry Mediastinum Immunotherapy respiratory system Middle Aged medicine.disease medicine.anatomical_structure 030220 oncology & carcinogenesis Monoclonal Female Radiology Lymph Nodes business |
| Zdroj: | Radiology. 289(2) |
| ISSN: | 1527-1315 |
| Popis: | Pembrolizumab is a programmed cell death protein 1, or PD-1, inhibitor therapy immunotherapy for patients with advanced melanoma. This report discusses a series of documented cases of sarcoid-like reactions associated with this therapy. Three patients with malignant melanoma developed metastatic disease and were treated with pembrolizumab immunotherapy. Subsequent imaging showed lymphadenopathy in the mediastinum and hilar regions that was confirmed to represent a sarcoid-like reaction at histologic examination. Radiologists should be aware of the association between pembrolizumab and the development of sarcoid-like reactions to avoid inaccurately ascribing these imaging findings to metastatic disease. Clinical presentation, biopsy, radiographic evidence of bilateral hilar lymphadenopathy (with paratracheal lymphadenopathy), and elevated serum angiotensin-converting enzyme levels aid in the diagnosis of sarcoid-like reactions and help avoid these reactions being mistaken for recurrent or metastatic disease. |
| Databáze: | OpenAIRE |
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