The expression and significance of microRNA in different stages of colorectal cancer
| Autor: | Yaochun Lv, Qing Liu, Weisheng Zhang, Xinlong Shi, Xiongfei Yang, Binbin Du, Dewang Wu, Tao Wang, Zhuolong Zhou |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine tumor Colon Colorectal cancer Normal tissue colorectal cancer Disease 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation microRNA Biomarkers Tumor Humans Medicine Gene Neoplasm Staging Oligonucleotide Array Sequence Analysis business.industry Rectum Computational Biology Cancer Clinical Trial/Experimental Study General Medicine medicine.disease target genes digestive system diseases Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Colonic Neoplasms Disease Progression Cancer research Female DNA microarray business Research Article |
| Zdroj: | Medicine |
| ISSN: | 0025-7974 |
| DOI: | 10.1097/md.0000000000009635 |
| Popis: | Background: The aim of this study is to compare microRNA expression patterns in different stages of colorectal cancer (CRC) and to discuss the significance of the application of microRNAs in the clinical treatment of CRC. Methods: The study used gene chip technology to analyze genetic sequences in CRC tissues and surrounding normal tissues at different cancer stages. The bioinformatics profiles of the target genes of the different microRNAs were analyzed to clarify the target gene-related pathways and their functions in the disease. Results: A total of 368 target genes with differential expression, including 275 upregulated and 93 downregulated genes, were screened from CRC patients in different stages of the disease. These microRNAs participated widely in the occurrence and development processes of CRC. The microRNA expression profiles obviously differed in tissues at different CRC stages. Conclusion: microRNA regulation of CRC samples can be used as a tool to control the occurrence and development of tumor cells. |
| Databáze: | OpenAIRE |
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