Analysis of environmental carcinogens associated with the incidence of lung cancer
| Autor: | Yoichi Nakanishi, Nobuyuki Sera, Satoru Inuzuka, Nobuyuki Hara, Hiroshi Tokiwa |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Lung Neoplasms Mutagen Toxicology medicine.disease_cause chemistry.chemical_compound Dry weight Risk Factors Salmonella Internal medicine medicine Humans Tuberculosis Lung cancer Lung Carcinogen Aged Fluoranthene Mutagenicity Tests Chemistry Incidence Respiratory disease General Medicine Middle Aged medicine.disease Carcinogens Environmental Survival Rate medicine.anatomical_structure Endocrinology Environmental Pollutants Female Respiratory tract |
| Zdroj: | Toxicology Letters. 99:33-41 |
| ISSN: | 0378-4274 |
| DOI: | 10.1016/s0378-4274(98)00136-2 |
| Popis: | It is presumed that carcinogens present in human lungs contribute to the incidence of lung cancer. Most of the carcinogens are inhaled in lung alveoli with particulate matter through the respiratory tract. On the basis of chemical analysis of 256 lung specimens with carcinomas resected in the period 1991 1996, the concentration of 1-nitropyrene (1-NP) was 19.7+/-10.5 pg/g of dry weight, and that of the dinitropyrenes (DNP) was 3.50+/-0.14-6.26+/-1.76. In addition, 2-nitrofluoranthene (NF) and 3-NF were detected at a higher level of 38.6+/-17.2 and 39.1+/-14.2, respectively, pg/g of dry weight. Concentrations of benzo[a]pyrene, benzo[e]pyrene, benzo[k]fluoranthene and benzo[ghi]perylene in 37 specimens collected in the period 1991 1996, were in the range of 138+/-82-399+/-220 pg/g of dry weight. No difference was found in the concentration of chemicals deposited in lung specimens from patients with lung cancer and tuberculosis as a control. By following the prognosis of 112 patients with carcinomas, we found that the deposition of 1-NP, 1,3-DNP, and 3-NF in lung tissues influenced their 5-year-survival after determination of chemicals. Lung specimens were divided into two groups of higher and lower chemical concentrations at the levels of 18 pg/g for 1-NP, 15 for 1,3-DNP, and 35 for 3-NF, and the findings were statistically analyzed by adjusting for age, gender, smoking status and cell type. The 5-year-survival of patients was markedly lower in the higher concentration group than the lower group. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect