Postsynaptic endocannabinoid release is critical to long-term depression in the striatum
| Autor: | Gregory L. Gerdeman, David M. Lovinger, Jennifer Ronesi |
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| Rok vydání: | 2002 |
| Předmět: |
Cannabinoid receptor
Polyunsaturated Alkamides Receptors Drug Striatum Arachidonic Acids In Vitro Techniques Mice Postsynaptic potential Metaplasticity Cannabinoid Receptor Modulators Animals Dronabinol Long-term depression Receptors Cannabinoid Mice Knockout Neurons Neuronal Plasticity Chemistry Cannabinoids General Neuroscience Excitatory Postsynaptic Potentials Neural Inhibition Endocannabinoid system Corpus Striatum Electric Stimulation nervous system Synaptic plasticity Synapses Retrograde signaling lipids (amino acids peptides and proteins) Neuroscience Endocannabinoids |
| Zdroj: | Nature neuroscience. 5(5) |
| ISSN: | 1097-6256 |
| Popis: | The striatum functions critically in movement control and habit formation. The development and function of cortical input to the striatum are thought to be regulated by activity-dependent plasticity of corticostriatal glutamatergic synapses. Here we show that the induction of a form of striatal synaptic plasticity, long-term depression (LTD), is dependent on activation of the CB1 cannabinoid receptor. LTD was facilitated by blocking cellular endocannabinoid uptake, and postsynaptic loading of anandamide (AEA) produced presynaptic depression. The endocannabinoid necessary for striatal LTD is thus likely to be released postsynaptically as a retrograde messenger. These findings demonstrate a new role for endocannabinoids in the induction of long-term synaptic plasticity in a circuit necessary for habit formation and motor control. |
| Databáze: | OpenAIRE |
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