Noninvasive Detection of Mitochondrial Dysfunction in Ocular Hypertension and Primary Open-angle Glaucoma
| Autor: | Yanin Suwan, Richard B Rosen, Matthew G. Field, Shelley Mo, Alexander Pinhas, Robert Ritch, Brian D Krawitz, Reena Garg, Lawrence S. Geyman |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Retinal Ganglion Cells Intraocular pressure medicine.medical_specialty Mitochondrial Diseases genetic structures Open angle glaucoma New York Glaucoma Ocular hypertension Diagnostic Techniques Ophthalmological Retinal ganglion Multimodal Imaging Retina 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Optical coherence tomography Ophthalmology medicine Humans Macula Lutea Fluorescein Angiography Intraocular Pressure Aged medicine.diagnostic_test business.industry Retinal Middle Aged medicine.disease Fluorescein angiography eye diseases 030104 developmental biology Cross-Sectional Studies chemistry Case-Control Studies 030221 ophthalmology & optometry Female Ocular Hypertension sense organs business Biomarkers Glaucoma Open-Angle Tomography Optical Coherence |
| Zdroj: | Journal of glaucoma. 27(7) |
| ISSN: | 1536-481X |
| Popis: | PURPOSE To assess mitochondrial dysfunction in vivo in ocular hypertension (OHT) and primary open-angle glaucoma (POAG) using retinal metabolic analysis. PATIENTS AND METHODS This was an observational, cross-sectional study performed from November 2015 to October 2016 at the New York Eye and Ear Infirmary of Mount Sinai. Thirty-eight eyes with varying stages of POAG, 16 eyes with OHT, and 32 control eyes were imaged on a custom fundus camera modified to measure full retinal thickness fluorescence at a wavelength optimized to detect flavoprotein fluorescence (FPF). Optical coherence tomography was used to measure the retinal ganglion cell-plus layer (RGC+) thickness. Macular FPF and the ratio of macular FPF to RGC+ thickness were the primary outcome variables and were compared among the three groups using an age-adjusted linear regression model. A mixed-effects model was used to assess correlations between FPF variables and clinical characteristics. RESULTS Both macular FPF and the macular FPF/RGC+ thickness ratio were significantly increased in OHT compared with control eyes (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|