Hormaomycins B and C: New Antibiotic Cyclic Depsipeptides from a Marine Mudflat-Derived Streptomyces sp
| Autor: | Beomkoo Chung, Dong-Chan Oh, Jongheon Shin, Ki-Bong Oh, Munhyung Bae |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Aquatic Organisms
Gram-negative bacteria Stereochemistry Gram-positive bacteria Pharmaceutical Science Peptide Microbial Sensitivity Tests secondary metabolite Secondary metabolite Gram-Positive Bacteria Streptomyces Article Microbiology Depsipeptides antibiotic Drug Discovery Gram-Negative Bacteria marine actinomycete medicine Pharmacology Toxicology and Pharmaceutics (miscellaneous) lcsh:QH301-705.5 Alanine chemistry.chemical_classification Depsipeptide hormaomycin peptide biology biology.organism_classification Anti-Bacterial Agents chemistry lcsh:Biology (General) Bacteria medicine.drug |
| Zdroj: | Marine Drugs, Vol 13, Iss 8, Pp 5187-5200 (2015) Marine Drugs Volume 13 Issue 8 Pages 5187-5200 MARINE DRUGS(13): 8 |
| ISSN: | 1660-3397 |
| Popis: | Alterations in microbial culture conditions may trigger the production of diverse bioactive secondary metabolites. While applying various culture conditions and monitoring secondary metabolite profiles using LC/MS, hormaomycins B and C (1 and 2) were discovered from a marine mudflat-derived actinomycete, Streptomyces sp., collected in Mohang, Korea. The planar structures of the hormaomycins, which bear structurally-unique units, such as 4-(Z)-propenylproline, 3-(2-nitrocyclopropyl)alanine, 5-chloro-1-hydroxypyrrol-2-carboxylic acid and b-methylphenylalanine, were established as the first natural analogues belonging to the hormaomycin peptide class. The absolute configurations of 1 and 2 were deduced by comparing their CD spectra with that of hormaomycin. These hormaomycins exhibited significant inhibitory effects against various pathogenic Gram-positive and Gram-negative bacteria. |
| Databáze: | OpenAIRE |
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