Determinants of exhaled nitric oxide levels in healthy, nonsmoking African American adults
| Autor: | Sabrena Mervin-Blake, David W. Hauswirth, Kistie B. Patch, John S. Sundy, Sallie D. Allgood, Andrew S. Allen, Katie M. Alexander, Patrice D. McNair, Carolyn A. Fernandez, Marc C. Levesque |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Intraclass correlation Immunology Nitric Oxide Cohort Studies Reference Values Internal medicine Immunology and Allergy Medicine Humans Expiration Respiratory Tract Infections Asthma Eosinophil cationic protein Sex Characteristics biology business.industry C-reactive protein respiratory system Immunoglobulin E medicine.disease respiratory tract diseases Black or African American Blood pressure Exhalation Exhaled nitric oxide Multivariate Analysis biology.protein Female business Body mass index |
| Zdroj: | The Journal of allergy and clinical immunology. 121(2) |
| ISSN: | 1097-6825 |
| Popis: | Background Asthma is a significant cause of morbidity and mortality for African Americans. Fraction of exhaled nitric oxide (FeNO) levels are increased in patients with asthma, and airway levels of nitric oxide metabolites regulate airway inflammation and airway diameter. More needs to be known about the factors that regulate FeNO. There is a need for FeNO reference values for African Americans. Objective We sought to establish reference values and identify factors associated with FeNO levels in healthy African American adults. Methods FeNO levels were measured in 895 healthy, nonsmoking African Americans between the ages of 18 and 40 years. FeNO measurements were repeated in 84 subjects. Factors potentially associated with FeNO were measured, including blood pressure, height, weight, and serum total IgE, eosinophil cationic protein, C-reactive protein, and nitrate levels. Data on respiratory symptoms, including upper respiratory tract infection (URI) symptoms, were collected. Univariate and multivariate analyses of the relationship between these variables and FeNO levels were performed. Results In healthy, nonsmoking African Americans FeNO levels were stable during repeated measurements (intraclass correlation coefficient, 0.81). Sex ( P P P = .0002) contributed significantly to FeNO variability but together accounted for less than 50% of the variation in FeNO levels. Conclusion The high correlation between repeated measurements of FeNO and the low correlation coefficients of known factors associated with FeNO suggest that other factors might contribute substantially to variability of FeNO levels in African Americans. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect