An Evaluation of CD61 Immunohistochemistry in Identification of Vascular Invasion in Follicular Thyroid Neoplasms
| Autor: | Nicole A. Cipriani, Vincent Cracolici, Kammi J. Henriksen, Megan Parilla |
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| Rok vydání: | 2019 |
| Předmět: |
Adenoma
Adult Blood Platelets Male 0301 basic medicine endocrine system Pathology medicine.medical_specialty Adolescent endocrine system diseases Fibrin Pathology and Forensic Medicine Thyroid carcinoma Young Adult 03 medical and health sciences 0302 clinical medicine Adenocarcinoma Follicular Follicular phase Biomarkers Tumor Humans Medicine Neoplasm Invasiveness Thyroid Neoplasms Aged Aged 80 and over Original Paper biology business.industry Thyroid Integrin beta3 Middle Aged Neoplastic Cells Circulating medicine.disease Immunohistochemistry Thrombosis 030104 developmental biology medicine.anatomical_structure Oncology Otorhinolaryngology 030220 oncology & carcinogenesis biology.protein Female business CD61 Immunostaining |
| Zdroj: | Head Neck Pathol |
| ISSN: | 1936-0568 |
| DOI: | 10.1007/s12105-019-01048-8 |
| Popis: | The identification of vascular invasion in follicular thyroid neoplasms is essential for categorizing lesions as benign (follicular adenomas) or malignant (follicular thyroid carcinomas). Among the histologic criteria diagnostic of true vascular invasion is tumor-cell associated thrombosis, including fibrin deposition and platelet clumping. This study aims to evaluate whether an immunohistochemical stain for the platelet-associated protein CD61 could assist in identifying tumor-associated thromboses and thereby confirm vascular invasion in follicular thyroid neoplasms. Histologic review and CD61 immunostaining of 19 atypical follicular adenomas, 13 non-metastatic follicular thyroid carcinomas, and 11 metastatic follicular thyroid carcinomas was performed. Linear arrays or clustered groups of CD61-expressing intravascular platelets were present in 51% of cases overall, including 54% of follicular thyroid carcinomas and 47% of follicular adenomas, mostly within intracapsular or peritumoral vessels. In three follicular thyroid carcinomas (all with distant metastases), CD61-expressing platelets were present in association with intravascular tumor cells. This finding was not present in adenomas. CD61 staining alone did not distinguish between atypical follicular adenomas, non-metastatic carcinomas, and metastatic carcinomas. When present in association with intravascular tumor cells, however, CD61-expressing platelets may serve as a marker for vascular invasion and aid in the diagnosis of follicular thyroid carcinoma. |
| Databáze: | OpenAIRE |
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