Age associations with neural processing of reward anticipation in adolescents with bipolar disorders

Autor: Eric A. Youngstrom, Snežana Urošević, Kathleen M. Thomas, Monica Luciana, Jonathan B. Jensen
Rok vydání: 2016
Předmět:
Male
Aging
MID
monetary incentive delay task
Bipolar Disorder
Nacc
nucleus accumbens
Brain mapping
lcsh:RC346-429
Developmental psychology
0302 clinical medicine
ADHD
attention-deficit/hyperactivity disorder
Image Processing
Computer-Assisted
Young adult
Brain Mapping
medicine.diagnostic_test
ACC
anterior cingulate cortex
fMRI
Brain
Regular Article
Cognition
Magnetic Resonance Imaging
Anticipation
Adolescence
BAS dysregulation
medicine.anatomical_structure
Neurology
DLPFC
dorsolateral prefrontal cortex
lcsh:R858-859.7
SUD
substance use disorders
Female
Psychology
Psychopathology
Clinical psychology
Adolescent
Cognitive Neuroscience
lcsh:Computer applications to medicine. Medical informatics
OFC
orbitofrontal cortex
Young Adult
03 medical and health sciences
BD
bipolar disorders
Reward
medicine
Humans
Radiology
Nuclear Medicine and imaging
Bipolar disorder
lcsh:Neurology. Diseases of the nervous system
Analysis of Variance
Motivation
medicine.disease
PCC
posterior cingulate cortex
030227 psychiatry
Dorsolateral prefrontal cortex
BAS
behavioral approach system
Linear Models
Neurology (clinical)
Functional magnetic resonance imaging
030217 neurology & neurosurgery
Zdroj: NeuroImage : Clinical
NeuroImage: Clinical, Vol 11, Iss C, Pp 476-485 (2016)
ISSN: 2213-1582
DOI: 10.1016/j.nicl.2016.03.013
Popis: Reward/behavioral approach system hypersensitivity is implicated in bipolar disorders (BD) and in normative development during adolescence. Pediatric onset of BD is associated with a more severe illness course. However, little is known about neural processing of rewards in adolescents with BD or developmental (i.e., age) associations with activation of these neural systems. The present study aims to address this knowledge gap. The present sample included 21 adolescents with BD and 26 healthy adolescents, ages 13 to 19. Participants completed a functional magnetic resonance imaging (fMRI) protocol using the Monetary Incentive Delay (MID) task. Behavioral performance was similar between groups. Group differences in BOLD activation during target anticipation and feedback anticipation periods of the task were examined using whole-brain analyses, as were group differences in age effects. During both target anticipation and feedback anticipation, adolescents with BD, compared to adolescents without psychopathology, exhibited decreased engagement of frontal regions involved in cognitive control (i.e., dorsolateral prefrontal cortex). Healthy adolescents exhibited age-related decreases, while adolescents with BD exhibited age-related increases, in activity of other cognitive control frontal areas (i.e., right inferior frontal gyrus), suggesting altered development in the BD group. Longitudinal research is needed to examine potentially abnormal development of cognitive control during reward pursuit in adolescent BD and whether early therapeutic interventions can prevent these potential deviations from normative development.
Highlights • We examined reward processing in adolescents with and without bipolar disorders. • Adolescents with BD engaged cognitive control regions less when processing rewards. • Adolescents with BD failed to show age-related activations of frontal regions. • Group and group-by-age effects were not due to comorbidities or symptom state.
Databáze: OpenAIRE
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