Vitamin B-6 intake is related to physical performance in European older adults: results of the New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE) study
| Autor: | Claudio Franceschi, Agnes A M Berendsen, Stephan J. L. Bakker, Edith J. M. Feskens, Aurelia Santoro, Corinne Malpuech-Brugère, Lisette C. P. G. M. de Groot, Agata Bialecka-Debek, Ido P. Kema, Nathalie Meunier, Marco Mensink, Susan J. Fairweather-Tait, Amy Jennings, Katarzyna Rolf, Pol Grootswagers, Carolien P J Deen |
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| Přispěvatelé: | Guided Treatment in Optimal Selected Cancer Patients (GUTS), Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), Wageningen University and Research [Wageningen] (WUR), University of Groningen [Groningen], University of Bologna/Università di Bologna, Lobachevsky State University of Nizhny Novgorod, Lobachevsky State University [Nizhni Novgorod], Centre de Recherche en Nutrition Humaine Auvergne [CHU Clermont-Ferrand] (CRNH A), Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), CHU Clermont-Ferrand-CHU Clermont-Ferrand, Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Centre de Recherche en Nutrition Humaine - Ile de France (CRNH - IDF), Warsaw University of Life Sciences (SGGW), University of East Anglia [Norwich] (UEA), University of Bologna, University of Nizhny Novgorod, Grootswagers, Pol, Mensink, Marco, Berendsen, Agnes A M, Deen, Carolien P J, Kema, Ido P, Bakker, Stephan J L, Santoro, Aurelia, Franceschi, Claudio, Meunier, Nathalie, Malpuech-Brugère, Corinne, Bialecka-Debek, Agata, Rolf, Katarzyna, Fairweather-Tait, Susan, Jennings, Amy, Feskens, Edith J M, de Groot, Lisette C P G M |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Aging Homocysteine Nutrition and Disease muscle Medicine (miscellaneous) Physiology niacin AcademicSubjects/MED00160 Healthy Aging chemistry.chemical_compound 0302 clinical medicine Voeding en Ziekte Medicine 030212 general & internal medicine Human Nutrition & Health 0303 health sciences education.field_of_study Nutrition and Dietetics Hand Strength Humane Voeding & Gezondheid Physical Functional Performance Nutritional Biology Europe Original Research Communications vitamin B-6 Quartile Female Niacin Vitamin Population Nutritional Status folate 03 medical and health sciences AcademicSubjects/MED00060 physical function Humans Vitamin B12 education Exercise 030304 developmental biology Aged VLAG vitamin B-12 Global Nutrition Wereldvoeding business.industry homocysteine Physical activity level Vitamin B 6 Diet B vitamins chemistry Dietary Supplements business [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition |
| Zdroj: | American Journal of Clinical Nutrition, 113(4), 781-789. Oxford University Press The American journal of clinical nutrition, 113(4), 781-789 The American journal of clinical nutrition 113 (2021) 4 The American Journal of Clinical Nutrition The American Journal of Clinical Nutrition, 2021, 113 (4), pp.781-789. ⟨10.1093/ajcn/nqaa368⟩ American Journal of Clinical Nutrition American Journal of Clinical Nutrition, American Society for Nutrition, 2021, 113 (4), pp.781-789. ⟨10.1093/ajcn/nqaa368⟩ |
| ISSN: | 0002-9165 1938-3207 |
| DOI: | 10.1093/ajcn/nqaa368⟩ |
| Popis: | International audience; ABSTRACT Background Maintenance of high physical performance during aging might be supported by an adequate dietary intake of niacin, vitamins B-6 and B-12, and folate because these B vitamins are involved in multiple processes related to muscle functioning. However, not much is known about the association between dietary intake of these B vitamins and physical performance. Objectives The objectives of this study were to investigate the association between dietary intake of niacin, vitamins B-6 and B-12, and folate and physical performance in older adults and to explore mediation by niacin status and homocysteine concentrations. Methods We used baseline data from the New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE) trial, which included n = 1249 healthy older adults (aged 65–79 y) with complete data on dietary intake measured with 7-d food records and questionnaires on vitamin supplement use and physical performance measured with the short physical performance battery and handgrip dynamometry. Associations were assessed by adjusted linear mixed models. Results Intake of vitamin B-6 was related to lower chair rise test time [β: –0.033 ± 0.016 s (log); P = 0.043]. Vitamin B-6 intake was also significantly associated with handgrip strength, but for this association, a significant interaction effect between vitamin B-6 intake and physical activity level was found. In participants with the lowest level of physical activity, higher intake of vitamin B-6 tended to be associated with greater handgrip strength (β: 1.5 ± 0.8 kg; P = 0.051), whereas in participants in the highest quartile of physical activity, higher intake was associated with lower handgrip strength (β: –1.4 ± 0.7 kg; P = 0.041). No evidence was found for an association between intake of niacin, vitamin B-12, or folate and physical performance or for mediation by niacin status or homocysteine concentrations. Conclusions Vitamin B-6 intake was associated with better chair rise test time in a population of European healthy older adults and also with greater handgrip strength in participants with low physical activity only. Homocysteine concentrations did not mediate these associations. The NU-AGE trial was registered at clinicaltrials.gov as NCT01754012. |
| Databáze: | OpenAIRE |
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