Biased intensity judgements of visceral sensations after learning to fear visceral stimuli
| Autor: | Ilse Van Diest, Nathalie Weltens, Katja Wiech, Johan W.S. Vlaeyen, Huynh Giao Ly, Jonas Zaman, Victoria J. Madden, Julie Iven, Lukas Van Oudenhove |
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| Přispěvatelé: | Zaman, Jonas, Madden, Victoria J, Iven, Julie, Wiech, Katja, Weltens, Nathalie, Ly, Huynh Giao, Blaeyen, JWS, Van Oudenhove, Lukas, Van Diest, Ilse, RS: FPN CPS I, Section Experimental Health Psychology |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Reflex Startle IRRITABLE-BOWEL-SYNDROME ACCURACY Audiology Fear-potentiated startle Developmental psychology 0302 clinical medicine ANXIETY Fear conditioning media_common drift diffusion 05 social sciences PAIN Pain Perception Fear Visceral Pain Neurology Interoceptive fear learning Anxiety Female HEALTH medicine.symptom Psychology perceptual decision-making medicine.medical_specialty DISORDERS media_common.quotation_subject Decision Making Stimulus (physiology) 050105 experimental psychology VALIDATION Judgment Young Adult 03 medical and health sciences Esophagus Perception Reaction Time medicine differential conditioning Humans Learning Computer Simulation 0501 psychology and cognitive sciences Fear processing in the brain Analysis of Variance Psychological Tests Visceral pain PERCEPTUAL DISCRIMINATION Electric Stimulation visceral intensity perception Associative learning MODEL interoceptive fear learning Anesthesiology and Pain Medicine Acoustic Stimulation Neurology (clinical) SENSITIVITY INDEX Software 030217 neurology & neurosurgery |
| Zdroj: | The Journal of Pain, 18(10), 1197-1208. Churchill Livingstone |
| ISSN: | 1528-8447 1526-5900 |
| Popis: | A growing body of research has identified fear of visceral sensations as a potential mechanism in the development and maintenance of visceral pain disorders. However, the extent to which such learned fear affects visceroception remains unclear. To address this question, we used a differential fear conditioning paradigm with nonpainful esophageal balloon distensions of 2 different intensities as conditioning stimuli (CSs). The experiment comprised of preacquisition, acquisition, and postacquisition phases during which participants categorized the CSs with respect to their intensity. The CS1 was always followed by a painful electrical stimulus (unconditioned stimulus) during the acquisition phase and in 60% of the trials during postacquisition. The second stimulus (CS) was never associated with pain. Analyses of galvanic skin and startle eyeblink responses as physiological markers of successful conditioning showed increased fear responses to the CS1 compared with the CS, but only in the group with the low-intensity stimulus as CS1. Computational modeling of response times and response accuracies revealed that differential fear learning affected perceptual decision-making about the intensities of visceral sensations such that sensations were more likely to be categorized as more intense. These results suggest that associative learning might indeed contribute to visceral hypersensitivity in functional gastrointestinal disorders. Perspective: This study shows that associative fear learning biases intensity judgements of visceral sensations toward perceiving such sensations as more intense. Learning-induced alterations in visceroception might therefore contribute to the development or maintenance of visceral pain. ispartof: The Journal of Pain vol:18 issue:10 pages:1197-1208 ispartof: location:United States status: published |
| Databáze: | OpenAIRE |
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