Community-based lung cancer screening by low-dose computed tomography in China: First round results and a meta-analysis
| Autor: | Kexin Chen, Yubei Huang, Xiaonan Cui, Marleen Vonder, Shuxuan Fan, Grigory Sidorenkov, Monique D. Dorrius, Shiyuan Liu, Geertruida H. de Bock, Rozemarijn Vliegenthart, Fengju Song, Yingru Zhao, Zhaoxiang Ye, Yihui Du, Yanju Li, Harry J.M. Groen |
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| Přispěvatelé: | Cardiovascular Centre (CVC), Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Life Course Epidemiology (LCE) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty China Lung Neoplasms Disease Internal medicine medicine Humans Mass Screening Radiology Nuclear Medicine and imaging Stage (cooking) Lung cancer Lung Early Detection of Cancer business.industry Carcinoma in situ General Medicine medicine.disease medicine.anatomical_structure Meta-analysis Adenocarcinoma Female business Tomography X-Ray Computed Lung cancer screening |
| Zdroj: | European Journal of Radiology, 144:109988. ELSEVIER IRELAND LTD |
| ISSN: | 0720-048X |
| Popis: | OBJECTIVE: To evaluate the efficiency of low-dose computed tomography (LDCT) screening for lung cancer in China by analyzing the baseline results of a community-based screening study accompanied with a meta-analysis.METHODS: A first round of community-based lung cancer screening with LDCT was conducted in Tianjin, China, and a systematic literature search was performed to identify LDCT screening and registry-based clinical studies for lung cancer in China. Baseline results in the community-based screening study were described by participant risk level and the lung cancer detection rate was compared with the pooled rate among the screening studies. The percentage of patients per stage was compared between the community-based study and screening and clinical studies.RESULTS: In the community-based study, 5523 participants (43.6% men) underwent LDCT. The lung cancer detection rate was 0.5% (high-risk, 1.2%; low-risk, 0.4%), with stage I disease present in 70.0% (high-risk, 50.0%; low-risk, 83.3%), and the adenocarcinoma present in 84.4% (high-risk, 61.5%; low-risk, 100%). Among all screen-detected lung cancer, women accounted for 8.3% and 66.7% in the high- and low-risk group, respectively. In the screening studies from mainland China, the lung cancer detection rate 0.6% (95 %CI: 0.3%-0.9%) for high-risk populations. The proportions with carcinoma in situ and stage I disease in the screening and clinical studies were 76.4% (95 %CI: 66.3%-85.3%) and 15.2% (95 %CI: 11.8%-18.9%), respectively.CONCLUSIONS: The stage shift of lung cancer due to screening suggests a potential effectiveness of LDCT screening in China. Nearly 70% of screen-detected lung cancers in low-risk populations are identified in women. |
| Databáze: | OpenAIRE |
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