Increased peroxidase activity in Pendred's syndrome with hypothyroidism
| Autor: | Makiko Yamamoto, Toshzro Sakurada, Katsumi Yoshida, Shintaro Saito, Kaoru Yoshinaga |
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| Rok vydání: | 1976 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Goiter endocrine system diseases medicine.medical_treatment Thyroid Gland Thyrotropin chemistry.chemical_element Deafness Thyroid Function Tests Iodine Thyroglobulin Thyroid function tests General Biochemistry Genetics and Molecular Biology Hypothyroidism Internal medicine medicine Humans Euthyroid Child medicine.diagnostic_test biology Chemistry Thyroid Syndrome General Medicine medicine.disease Endocrinology medicine.anatomical_structure Peroxidases Sephadex biology.protein hormones hormone substitutes and hormone antagonists Peroxidase |
| Zdroj: | The Tohoku Journal of Experimental Medicine. 119:103-113 |
| ISSN: | 1349-3329 0040-8727 |
| Popis: | An 8-year-old boy with goiter and bilateral nerve deafness had a 46% discharge of radioiodine after thiocyanate administration. He was clinically euthyroid. Although the serum total T4 was low (2.4 mug/100 ml) and TSH was significantly high (181 muU/ml), the serum total T3 was normal (152 ng/100ml). It was considered that the increased release of TSH by the feedback mechanism in response to the low T4 resulted in a quite normal level of serum T3. The thyroid gland demonstrated a low stable iodine content, an increase in MIT/DIT ration and a decrease in iodothyronine. The thyroglobulin behaved normally in Sephadex G-200 chromatography and immunoreaction. Thyroid tissue exhibited increased peroxidase activity as measured by I3 formation. Increased peroxidase activity may be related to the observed increase in serum level of TSH. |
| Databáze: | OpenAIRE |
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