Green synthesis and biological activities assessment of some new chromeno[2,3-b]pyridine derivatives
| Autor: | Masoumeh Ghaemi, Mostafa Asadbegy, Roya Karamian, Fatemeh Ghasemlou, Davood Azarifar, Mehdi Jaymand |
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| Rok vydání: | 2021 |
| Předmět: |
Green chemistry
DPPH Pyridines 010402 general chemistry 01 natural sciences Antioxidants Catalysis Inorganic Chemistry chemistry.chemical_compound Dimedone Drug Discovery Pyridine Physical and Theoretical Chemistry Fourier transform infrared spectroscopy Magnetite Nanoparticles Molecular Biology 010405 organic chemistry Organic Chemistry General Medicine Carbon-13 NMR 0104 chemical sciences Thiourea dioxide chemistry Solvents Potato dextrose agar Information Systems Nuclear chemistry |
| Zdroj: | Molecular diversity. 26(2) |
| ISSN: | 1573-501X |
| Popis: | Magnetite nanoparticles (MNPs) composed of γ-Fe2O3 and hydroxyapatite (HAp) were modified by hexamethylen-1,6-diisocyanate (HMDI) followed by thiourea dioxide and used as recyclable catalyst for the synthesis of some newly derivatives of chromeno[2,3-b]pyridine. The products were synthesized in excellent yields via one-pot three-component reactions of 3-cyano-6-hydroxy-4-methyl-pyridin-2(1H)-one with aldehydes and dimedone under solvent-free conditions. The successful synthesis of products were confirmed using Fourier transform infrared (FTIR), proton/carbon nuclear magnetic resonance (1H/13C NMR), and mass spectroscopies as well as physical data (e.g., melting points and elemental composition). The in vitro antioxidant and antifungal activities of the synthesized samples were evaluated using scavenging effects on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and potato dextrose agar (PDA) medium, respectively. Based on results, the chromeno[2,3-b]pyridine derivatives exhibited excellent biological activities that qualified them for biomedical applications. |
| Databáze: | OpenAIRE |
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