Cord blood IgE. II. Prediction of atopic disease. A follow-up at the age of 18 months
| Autor: | L. B. Lassen, A. Holmskov, O. Østerballe, Steffen Husby, L G Hansen, K. Storm, Susanne Halken, Arne Høst |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Hypersensitivity
Immediate Male Denmark Immunology Disease Immunoglobulin E Sensitivity and Specificity Atopy Cohort Studies Predictive Value of Tests medicine Immunology and Allergy Humans Family history biology business.industry Infant medicine.disease Fetal Blood Cord blood Predictive value of tests biology.protein Female Phadebas business Cohort study Follow-Up Studies |
| Zdroj: | Allergy. 47(4 Pt 2) |
| ISSN: | 0105-4538 |
| Popis: | Screening of total IgE in 2814 cord blood samples was analysed by Phadebas IgE PRIST in 2 1-year birth cohorts (1983-1984 and 1985-1986) in Denmark (n = 1189 + 1625). For follow-up we chose all infants with cord blood IgE greater than or equal to 0.5 kU/l and a randomly chosen group of the same size with cord blood IgE less than 0.5 kU/l. A total of 762 infants were clinically evaluated at 18 months of age. A diagnosis of definite atopy, probable atopy or no atopy, including both IgE and non-IgE mediated disease was established. Applying different cord blood IgE cut-off values (0.3, 0.5, 0.8, 1.1) we did not find an excess of atopic infants among those with elevated cord blood IgE irrespective of the chosen cut-off value. Atopic predisposition or family history of atopic disease was defined as at least one parent or older sibling with atopic disease. Significantly more infants with a family history developed atopy at 18 months. In the 2 series the positive predictive values of cord blood IgE greater than or equal to 0.5 were 43% and 46% and the sensitivities were 17% and 15%. The predictive values of having a family history were 48% and 44% and the sensitivities were 55% and 58%. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text