Ubiquitylation at Stressed Replication Forks: Mechanisms and Functions
| Autor: | Niels Mailand, Ann Schirin Mirsanaye, Dimitris Typas |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
DNA Replication
0303 health sciences DNA Repair Cell division DNA repair DNA damage Ubiquitination DNA replication Cell Biology Biology Genome Genomic Instability Replication (computing) Cell biology 03 medical and health sciences 0302 clinical medicine Gene duplication Humans Replisome 030217 neurology & neurosurgery DNA Damage 030304 developmental biology |
| Zdroj: | Mirsanaye, A S, Typas, D & Mailand, N 2021, ' Ubiquitylation at Stressed Replication Forks : Mechanisms and Functions ', Trends in Cell Biology, vol. 31, no. 7, pp. 584-597 . https://doi.org/10.1016/j.tcb.2021.01.008 |
| ISSN: | 0962-8924 |
| DOI: | 10.1016/j.tcb.2021.01.008 |
| Popis: | Accurate duplication of chromosomal DNA is vital for faithful transmission of the genome during cell division. However, DNA replication integrity is frequently challenged by genotoxic insults that compromise the progression and stability of replication forks, posing a threat to genome stability. It is becoming clear that the organization of the replisome displays remarkable flexibility in responding to and overcoming a wide spectrum of fork-stalling insults, and that these transactions are dynamically orchestrated and regulated by protein post-translational modifications (PTMs) including ubiquitylation. In this review, we highlight and discuss important recent advances on how ubiquitin-mediated signaling at the replication fork plays a crucial multifaceted role in regulating replisome composition and remodeling its configuration upon replication stress, thereby ensuring high-fidelity duplication of the genome. |
| Databáze: | OpenAIRE |
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