Postnatal development of the autonomic and sensory innervation of the musculature in the rat urinary bladder
| Autor: | Holger Sann, Friedrich-Karl Pierau, Gabriele Walb |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Calcitonin Gene-Related Peptide media_common.quotation_subject Efferent Urinary Bladder Vasoactive intestinal peptide Neuromuscular Junction Neuropeptide Substance P Calcitonin gene-related peptide Biology Autonomic Nervous System Urination chemistry.chemical_compound Internal medicine medicine Animals Neuropeptide Y Neurons Afferent Rats Wistar media_common General Neuroscience Neuropeptide Y receptor Immunohistochemistry Rats Endocrinology chemistry Calcitonin Female |
| Zdroj: | Neuroscience Letters. 236:29-32 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/s0304-3940(97)00752-0 |
| Popis: | The postnatal development of the innervation of the muscle layer in the rat urinary bladder was analysed in whole mount preparations using immunohistochemistry against protein gene-product 9.5 (PGP; general neuronal marker), growth-associated protein 43 (GAP), dopamine β -hydroxylase (DBH), neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP) and substance P (SP). Immunoreactive nerve fibres for all markers were already present at birth. The density of PGP- and GAP-positive nerve fibres was similar and remained constant throughout the postnatal development. The rank order of densities for the other markers relative to PGP was NPY (129–189%)>CGRP (20–63%)>SP (7–23%)>DBH (7–12%)>VIP (2–11%). While the density of presumably efferent VIP- and DBH-positive fibres did not change postnatally, NPY-positive fibres reached adult density at the fifth postnatal day. Sensory CGRP- and SP-positive nerve fibres approached adult levels at the end of the second week, shortly before the micturition reflex was completely developed. The data suggest that a sufficient relative density of sensory and certain efferent elements might be a prerequisite for the development of the mature micturition reflex. |
| Databáze: | OpenAIRE |
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