Outcome of bimodality definitive chemoradiation does not differ from that of trimodality upfront neck dissection followed by adjuvant treatment for >6 cm lymph node (N3) head and neck cancer

Autor: Shih-Fan Lai, Tony Hsiang-Kuang Liang, Chun-Wei Wang, Tseng-Cheng Chen, Bing-Shen Huang, Wan-Yu Chen
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Larynx
medicine.medical_treatment
Respiratory System
Cancer Treatment
Oropharynx
0302 clinical medicine
Surgical oncology
Medicine and Health Sciences
030223 otorhinolaryngology
Lymph node
Multidisciplinary
Pharmaceutics
Chemoradiotherapy
Middle Aged
Prognosis
Combined Modality Therapy
Magnetic Resonance Imaging
Primary tumor
Surgical Oncology
Treatment Outcome
medicine.anatomical_structure
Oncology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Neck Dissection
Medicine
Female
Radiology
Anatomy
Adjuvant
Research Article
Clinical Oncology
Adult
medicine.medical_specialty
Science
Surgical and Invasive Medical Procedures
Throat
Cancer Chemotherapy
03 medical and health sciences
Drug Therapy
medicine
Chemotherapy
Humans
Aged
Neoplasm Staging
Retrospective Studies
business.industry
Head and neck cancer
Biology and Life Sciences
Cancers and Neoplasms
Cancer
Neck dissection
medicine.disease
Head and Neck Cancers
Pharynx
Lymph Nodes
Clinical Medicine
business
Digestive System
Neck
Zdroj: PLoS ONE, Vol 14, Iss 12, p e0225962 (2019)
PLoS ONE
ISSN: 1932-6203
Popis: Currently, data regarding optimal treatment modality, response, and outcome specifically for N3 head and neck cancer are limited. This study aimed to compare the treatment outcomes between definitive chemoradiotherapy (CCRT) to the neck and upfront neck dissection followed by adjuvant CCRT. Ninety-three N3 squamous cell carcinoma head and neck cancer patients were included. Primary tumor treatment was divided to definitive CCRT (CCRT group) or curative surgery followed by adjuvant CCRT (surgery group). Neck treatment was also classified into two treatment modalities: definitive CCRT to the neck (CCRT group) or curative neck dissection followed by adjuvant CCRT (neck dissection group). Overall, the 2-year overall survival (OS), local recurrence-free survival (LRFS), regional recurrence-free survival (RRFS), and distant metastasis-free survival (DMFS) were 51.8%, 47.3%, 45.6%, and 43.6%, respectively. In both oropharyngeal cancer and nonoropharyngeal cancer patients, in terms of OS, LRFS, RRFS or DMFS no difference was noted regarding primary tumor treatment (CCRT vs. surgery) or neck treatment (CCRT vs. neck dissection). In summary, N3 neck patients treated with definitive CCRT may achieve similar outcomes to those treated with upfront neck dissection followed by adjuvant CCRT. Caution should be made to avoid overtreatment for this group of patients.
Databáze: OpenAIRE
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