Automated Assessment of Thoracic-Abdominal Asynchrony in Patients with Morquio Syndrome
| Autor: | Mary C. Theroux, Tariq Rahman, Yan Zhu, Thomas H. Shaffer, Madhavi V. Ratnagiri, Shunji Tomatsu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Thorax
Medicine (General) Pediatrics medicine.medical_specialty Morquio syndrome Clinical Biochemistry Article 03 medical and health sciences R5-920 0302 clinical medicine medicine Outpatient clinic Respiratory function Respiratory system noninvasive pulmonary diagnostics business.industry automated pulmonary assessment medicine.disease thoracic-abdominal asynchrony medicine.anatomical_structure 030228 respiratory system Respiratory failure Abdomen business 030217 neurology & neurosurgery Rare disease |
| Zdroj: | Diagnostics Volume 11 Issue 5 Diagnostics, Vol 11, Iss 880, p 880 (2021) |
| ISSN: | 2075-4418 |
| DOI: | 10.3390/diagnostics11050880 |
| Popis: | Morquio syndrome is a rare disease caused by a disorder in the storage of mucopolysaccharides that affects multiple organs, including musculoskeletal, respiratory, cardiovascular, and digestive systems. Respiratory failure is one of the leading causes of mortality in Morquio patients thus, respiratory function testing is vital to the management of the disease. An automated respiratory assessment methodology using the pneuRIP device and a machine-learning algorithm was developed. pneuRIP is a noninvasive approach that uses differences between thoracic and abdominal movements (thoracic-abdominal asynchrony) during respiration to assess respiratory status. The technique was evaluated on 17 patients with Morquio (9 females and 8 males) between the ages of 2 and 57 years. The results of the automated technique agreed with the clinical assessment in 16 out of the 17 patients. It was found that the inverse cumulative percentage representation of the time delay between the thorax and abdomen was the most critical variable for accurate evaluation. It was demonstrated that the technique could be successfully used on patients with Morquio who have difficulty breathing with 100% compliance. This technique is highly accurate, portable, noninvasive, and easy to administer, making it suitable for a variety of settings, such as outpatient clinics, at home, and emergency rooms. |
| Databáze: | OpenAIRE |
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