PCSK9 concentrations in different stages of subclinical atherosclerosis and their relationship with inflammation
| Autor: | Ryan Chakravarty, Peter Olexa, Zdenka Hertelyová, Peter Štefanič, Vladimir Filip, Daniel Pella, Štefan Tóth, Monika Široká, Ivan Kopolovets, Peter Berek |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
pcsk9 Chemistry PCSK9 Inflammation General Chemistry 030204 cardiovascular system & hematology initiation plaque lcsh:Chemistry 03 medical and health sciences 030104 developmental biology 0302 clinical medicine lcsh:QD1-999 inflammation Subclinical atherosclerosis Immunology Materials Chemistry medicine cardiovascular diseases medicine.symptom atherosclerosis |
| Zdroj: | Open Chemistry, Vol 18, Iss 1, Pp 1011-1019 (2020) |
| ISSN: | 2391-5420 |
| Popis: | The aim of this study was to detect the concentrations of PCSK9 in various subclinical stages of atherosclerosis and to highlight its relationship with inflammation. One hundred and fifty-nine healthy patients were divided into three groups, based on the extent of atherosclerotic changes in the carotid artery: a group without identifiable atherosclerosis, cIMT>75‰and an asymptomatic plaque group. The PCSK9 was measured by ELISA and hsCRP by the immunoturbidimetric method. Vascular changes were identified by a carotid ultrasound. PCSK9 was elevated, when comparing the healthy group with the cIMT>75‰group; however, no significant increase was detected between cIMT>75‰and the asymptomatic plaque group. A positive linear correlation of the PCSK9 concentration and atherosclerotic changes was found; however, after the re-analysis in each group, this correlation persisted only in the group with still normal values. Additionally, a significant linear correlation was found between the PCSK9 concentrations and lipid parameters. However, no significant association was found with hsCRP. PCSK9 was found to be elevated only in cIMT>75‰, but not in the later plaque stage. A linear correlation of PCSK9 values was detected only in the group with still reference values. Based on this fact, we assumed the direct linear role of PCSK9 in initiating atherosclerosis; however, in the later phases, the relationship, which highlights other risk factors such as inflammation, is not linear. |
| Databáze: | OpenAIRE |
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