Stabilization of proteins by a bacteriophage T4 gene cloned in Escherichia coli
| Autor: | Barbara Randolph, Nina Irwin, Lee D. Simon, Gloria Binkowski |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Multidisciplinary
Genes Viral biology Lambda phage medicine.disease_cause biology.organism_classification Molecular biology Bacterial protein Bacteriophage Bacterial Proteins Human fibroblast interferon Interferon Type I Escherichia coli medicine T-Phages Cloning Molecular Gene Bacteria Interferon type I Research Article medicine.drug |
| Zdroj: | Proceedings of the National Academy of Sciences. 80:2059-2062 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.80.7.2059 |
| Popis: | The cloned bacteriophage T4 pin gene functions to stabilize several different kinds of proteins in Escherichia coli bacteria. Incomplete proteins such as puromycyl polypeptides, abnormal but complete proteins such as the lambda phage tsO protein, and labile eukaryotic proteins encoded by genes cloned in E. coli such as mature human fibroblast interferon are stabilized in cells in which the T4 pin gene is expressed. The cloned T4 pin gene does not seem to affect the turnover of normal E. coli proteins. |
| Databáze: | OpenAIRE |
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