Hippocampal Radial Glial Subtypes and Their Neurogenic Potential in Human Fetuses and Healthy and Alzheimer's Disease Adults
| Autor: | Sowmyalakshmi Rasika, Jean-Louis Benifla, Anne-Lise Delezoide, Homa Adle-Biassette, Gabor G. Kovacs, Eleonora Aronica, Philippe Manivet, Sara Cipriani, Pierre Gressens, Catherine Verney, Jeannette Nardelli, Ivan Milenkovic, Suonavy Khung, Isidre Ferrer, Nicolas Deriot |
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| Přispěvatelé: | Universitat de Barcelona |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Adolescent Cognitive Neuroscience Neurogenesis Hipocamp (Cervell) Gestational Age Nerve Tissue Proteins Biology Hippocampal formation Hippocampus 03 medical and health sciences Cellular and Molecular Neuroscience Young Adult Fetus Neural Stem Cells Alzheimer Disease medicine Humans Young adult Child Neurogenetics Progenitor Aged Aged 80 and over Neurons Dentate gyrus Age Factors Infant Newborn Infant Nestin Middle Aged Alzheimer's disease medicine.disease Neural stem cell 030104 developmental biology Ki-67 Antigen Malaltia d'Alzheimer Child Preschool Female Neurogenètica Hippocampus (Brain) Neuroscience |
| Zdroj: | Cipriani, S, Ferrer, I, Aronica, E, Kovacs, G G, Verney, C, Nardelli, J, Khung, S, Delezoide, A-L, Milenkovic, I, Rasika, S, Manivet, P, Benifla, J-L, Deriot, N, Gressens, P & Adle-Biassette, H 2018, ' Hippocampal Radial Glial Subtypes and Their Neurogenic Potential in Human Fetuses and Healthy and Alzheimer's Disease Adults ', Cerebral cortex (New York, N.Y. : 1991) . https://doi.org/10.1093/cercor/bhy096 Dipòsit Digital de la UB Universidad de Barcelona Recercat. Dipósit de la Recerca de Catalunya instname |
| DOI: | 10.1093/cercor/bhy096 |
| Popis: | Neuropathological conditions might affect adult granulogenesis in the adult human dentate gyrus. However, radial glial cells (RGCs) have not been well characterized during human development and aging. We have previously described progenitor and neuronal layer establishment in the hippocampal pyramidal layer and dentate gyrus from embryonic life until mid-gestation. Here, we describe RGC subtypes in the hippocampus from 13 gestational weeks (GW) to mid-gestation and characterize their evolution and the dynamics of neurogenesis from mid-gestation to adulthood in normal and Alzheimer's disease (AD) subjects. In the pyramidal ventricular zone (VZ), RGC density declined with neurogenesis from mid-gestation until the perinatal period. In the dentate area, morphologic and antigenic differences among RGCs were observed from early ages of development to adulthood. Density and proliferative capacity of dentate RGCs as well as neurogenesis were strongly reduced during childhood until 5 years, few DCX+ cells are seen in adults. The dentate gyrus of both control and AD individuals showed Nestin+ and/or GFAPδ+ cells displaying different morphologies. In conclusion, pools of morphologically, antigenically, and topographically diverse neural progenitor cells are present in the human hippocampus from early developmental stages until adulthood, including in AD patients, while their neurogenic potential seems negligible in the adult. Key words: adult neurogenesis, hippocampus, human fetal brain, neurogenesis, radial glial cells |
| Databáze: | OpenAIRE |
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