Melanin as a confounding factor in near infrared spectroscopy of skin

Autor:	Anna Matas, Geoff Taylor, Michael G. Sowa, Henry H. Mantsch
Rok vydání:	2002
Předmět:	integumentary system Chemistry Near-infrared spectroscopy Analytical chemistry Blood volume Chromophore Least squares Melanin Nuclear magnetic resonance In vivo Blood oxygenation sense organs Pigmented skin Absorption (electromagnetic radiation) Near infrared spectroscopy Spectroscopy
Zdroj:	Vibrational Spectroscopy. 28:45-52
ISSN:	0924-2031
DOI:	10.1016/s0924-2031(01)00144-8
Popis:	Blood oxygenation and blood volume are two clinically relevant parameters that can be determined noninvasively from near infrared in vivo spectra. As the number of medical applications based on near infrared technology grows, the necessity of extracting the same quality of information from all individuals increases as well. High epidermal melanin content masks the absorption of oxyhemoglobin and deoxyhemoglobin. Near infrared spectra were recorded in vivo from the forearm of subjects with light and highly pigmented skin. The spectra were analyzed using a modified Beer–Lambert Law and a least squares classifier. In the first iteration the analysis included the chromophores oxyhemoglobin, deoxyhemoglobin and water; in the second iteration the analysis included melanin as an additional chromophore. Including melanin in the fit results in a statistically significant (P Shedding New Light on Disease: Optical Diagnostics for the New Millennium, Winnipeg, Canada, June 25-30, 2000
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4037cb1c7db0449bd43daed6fc5133fb https://doi.org/10.1016/s0924-2031(01)00144-8 Zobrazit plný text záznamu Full Text from ScienceDirect