Synthesis of Marine Alkaloid: 8,9-Dihydrocoscinamide B and Its Analogues as Novel Class of Antileishmanial Agents
| Autor: | Suman Gupta, Leena Gupta, Nishi, Shraddha Palne, Archna Talwar, Prem M. S. Chauhan |
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| Rok vydání: | 2007 |
| Předmět: |
Class (set theory)
medicine.drug_class Stereochemistry Clinical Biochemistry Antiprotozoal Agents Pharmaceutical Science Carboxamide Biochemistry Chemical synthesis Indole Alkaloids Drug Discovery medicine Animals Organic chemistry Amastigote Molecular Biology Leishmania biology Bicyclic molecule Chemistry Alkaloid Organic Chemistry Kinetoplastida General Medicine biology.organism_classification In vitro Molecular Medicine |
| Zdroj: | ChemInform. 38 |
| ISSN: | 1522-2667 0931-7597 |
| DOI: | 10.1002/chin.200744189 |
| Popis: | A series of marine alkaloid 8,9-dihydrocoscinamide B, its analogues and indolylglyoxylamide derivatives have been synthesized and screened for their in vitro antileishmanial activity profile in promastigote and amastigote models. Compounds 7 and 10 have shown 99–100% inhibition against promastigotes and 97–98% inhibition against amastigotes at a concentration of 10 μg/ml. |
| Databáze: | OpenAIRE |
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