cAMP-Dependent Co-stabilization of Axonal Arbors from Adjacent Developing Neurons
| Autor: | Sandrine Couvet, Ahlem Assali, Yvrick Zagar, Melissa Nedjam, Antoine Chaffiol, Jens Duebel, Sarah Baudet, Xavier Nicol, Alice Louail, Fiona Roche, Martijn C. Sierksma |
|---|---|
| Přispěvatelé: | Neurosciences, Institut de la Vision, Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Gestionnaire, HAL Sorbonne Université 5, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Erasmus University Medical Center [Rotterdam] (Erasmus MC), Institut du Fer à Moulin (IFM - Inserm U1270 - SU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
retina pruning binocular map cooperation [SDV.BC]Life Sciences [q-bio]/Cellular Biology Biology Retinal ganglion General Biochemistry Genetics and Molecular Biology ooperation 03 medical and health sciences 0302 clinical medicine CAMP signaling 0502 economics and business Cyclic AMP medicine Humans [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Pruning (decision trees) 050207 economics Axon spontaneous activity lcsh:QH301-705.5 [SDV.BDD]Life Sciences [q-bio]/Development Biology axon Neurons Retina 050208 finance 05 social sciences dorso-lateral geniculate nucleus Axons 030104 developmental biology medicine.anatomical_structure retinal ganglion cells lcsh:Biology (General) nervous system [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] axonal branches competition Neuroscience 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Cell Reports, 33(1):108220. Cell Press Cell Reports Cell Reports, Elsevier Inc, 2020, 33 (1), pp.108220. ⟨10.1016/j.celrep.2020.108220⟩ Cell Reports, Vol 33, Iss 1, Pp 108220-(2020) Cell Reports, 2020, 33 (1), pp.108220. ⟨10.1016/j.celrep.2020.108220⟩ |
| ISSN: | 2211-1247 |
| Popis: | International audience; Axonal arbors in many neuronal networks are exuberant early during development and become refined by activity-dependent competitive mechanisms. Theoretical work proposed non-competitive interactions between co-active axons to co-stabilize their connections, but the demonstration of such interactions is lacking. Here, we provide experimental evidence that reducing cyclic AMP (cAMP) signaling in a subset of retinal ganglion cells favors the elimination of thalamic projections from neighboring neurons, pointing to a cAMP-dependent interaction that promotes axon stabilization. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|