Cerebral cortex and hippocampus respond differently after post-natal exposure to uranium

Autor: Olivia Delissen, Isabelle Dublineau, Philippe Voisin, Philippe Lestaevel, Claire-Marie Vacher, Mohammed Taouis, Helene Bensoussan, B. Dhieux
Přispěvatelé: Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Neurobiologie de l'Olfaction et Modélisation en Imagerie (NOeMI), Institut National de la Recherche Agronomique (INRA), Institute for Radioprotection and Nuclear Safety (IRSN), Laboratoire de radiotoxicologie expérimentale, Direction de la radioprotection de l'homme, Institut de Radioprotection et de Sûreté Nucléaire (IRSN/PRP-HOM/SRBE), Centre de Neurosciences Paris-Sud (CNPS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Institut des Neurosciences Paris-Saclay (NeuroPSI)
Rok vydání: 2013
Předmět:
Male
MESH: Hippocampus
STRESS
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
[SDV]Life Sciences [q-bio]
Hippocampus
MESH: Rats
Sprague-Dawley
Toxicology
Spatial memory
MESH: Animals
Newborn
Rats
Sprague-Dawley
PERIRHINAL CORTEX
chemistry.chemical_compound
0302 clinical medicine
Acetylcholinesterase
Heavy metal
Cerebral cortex
Behavior
Sleep
OBJECT RECOGNITION MEMORY
BRAIN CHOLINERGIC SYSTEM
DEPLETED URANIUM
WORKING-MEMORY
LEAD-EXPOSURE
RAT BRAIN
BEHAVIOR
NEUROTOXICITY
MESH: Behavior
Animal
MESH: Animals
MESH: Memory
0303 health sciences
Behavior
Animal
[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior
[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
6. Clean water
medicine.anatomical_structure
Uranium
MESH: Radioactive Pollutants
Acetylcholine
Radioactive Pollutants
medicine.drug
medicine.medical_specialty
MESH: Rats
MESH: Sleep
Central nervous system
Biology
03 medical and health sciences
Memory
Internal medicine
medicine
Animals
[INFO]Computer Science [cs]
Wakefulness
030304 developmental biology
MESH: Acetylcholine
MESH: Acetylcholinesterase
Entorhinal cortex
MESH: Cerebral Cortex
MESH: Male
Rats
MESH: Wakefulness
Endocrinology
Animals
Newborn
chemistry
Cholinergic
MESH: Uranium
030217 neurology & neurosurgery
Zdroj: Journal of Toxicological Sciences 5 (38), 803-811. (2013)
The Journal of Toxicological Sciences
The Journal of Toxicological Sciences, Japanese Society of Toxicology, 2013, 38 (5), pp.803-811
The Journal of Toxicological Sciences, Japanese Society of Toxicology, 2012, 38 (5), pp.803-11. ⟨10.2131/jts.38.803⟩
ISSN: 1880-3989
0388-1350
DOI: 10.2131/jts.38.803
Popis: International audience; The central nervous system (CNS) is known to be sensitive to pollutants during its development. Uranium (U) is a heavy metal that occurs naturally in the environment as a component of the earth's crust, and populations may therefore be chronically exposed to U through drinking water and food. Previous studies have shown that the CNS is a target of U in rats exposed in adulthood. We assessed the effects of U on behavior and cholinergic system of rats exposed from birth for 10 weeks at 10 mg.L⁻¹ or 40 mg.L⁻¹. For behavioral analysis, the sleep/wake cycle (recorded by telemetry), the object recognition memory and the spatial working memory (Y-maze) were evaluated. Acetylcholine (ACh) and acetylcholinesterase (AChE) levels were evaluated in the entorhinal cortex and hippocampus. At 40 mg.L⁻¹, U exposure impaired object recognition memory (-20%), but neither spatial working memory nor the sleep/wake cycle was impaired. A significant decrease was observed in both the ACh concentration (-14%) and AChE activity (-14%) in the entorhinal cortex, but not in the hippocampus. Any significant effect on behaviour and cholinergic system was observed at 10 mg U.L⁻¹. These results demonstrate that early exposure to U during postnatal life induces a structure cerebral-dependant cholinergic response and modifies such memory process in rats. This exposure to U early in life could have potential delayed effects in adulthood.
Databáze: OpenAIRE
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