Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain

Autor: Jan Wijnholds, Vania Broccoli, Andrea Ballabio, Yvette J. M. de Kok, Anneke I. den Hollander, Frans P.M. Cremers, Michela Ghiani
Rok vydání: 2002
Předmět:
Embryology
Rostral migratory stream
Elucidation of hereditary disorders and their molecular diagnosis
Molecular Sequence Data
Genes
Insect
Nerve Tissue Proteins
Biology
Eye
Mice
Retinitis pigmentosa
medicine
Animals
Drosophila Proteins
Humans
Amino Acid Sequence
experimenteel en klinisch onderzoek en behandeling. [Erfelijke en verworven vitreo-retinale aandoeningen]
Eye Proteins
In Situ Hybridization
Homeodomain Proteins
Retina
CRB1
Sequence Homology
Amino Acid
Neural tube
Brain
Gene Expression Regulation
Developmental
Membrane Proteins
Nuclear Proteins
Anatomy
medicine.disease
Neural stem cell
Cell biology
Homeobox Protein Nkx-2.2
medicine.anatomical_structure
Zona limitans intrathalamica
Drosophila
experimental and clinical research and treatment. [Hereditary and acquired vitreo-retinal disorders]
Opheldering van erfelijke ziekten en hun moleculaire diagnostiek
Retinal Dystrophies
Transcription Factors
Developmental Biology
Zdroj: Mechanisms of Development, 110, 1-2, pp. 203-7
Mechanisms of Development, 110, 203-7
ISSN: 0925-4773
DOI: 10.1016/s0925-4773(01)00568-8
Popis: Item does not contain fulltext Mutations in the human Crumbs homologue 1 (CRB1) gene cause severe retinal dystrophies. CRB1 is homologous to Drosophila Crumbs, a protein essential for establishing and maintaining epithelial polarity. We have isolated the mouse orthologue, Crb1, and analyzed its expression pattern in embryonic and post-natal stages. Crb1 is expressed exclusively in the eye, and the central nervous system. In the developing eye, expression of Crb1 is detected in the retinal progenitors, and later on becomes restricted to the differentiated photoreceptor cells where it remains active up to the adult stage. In the developing neural tube, expression of Crb1 is restricted to its most ventral structures, coinciding with the expression domain of Nkx2.2. In the adult brain, Crb1 expression is defined to areas where the production and migration of neurons occurs in adulthood.
Databáze: OpenAIRE
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