Gut microbiome diversity is associated with sleep physiology in humans

Autor: Sarah M. Lyle, Robert Smith, Ritishka Kapoor, Eileen J. Davidson, Jose V. Lopez, Esha Parikh, Jaime L. Tartar, Chase P. Donnelly, Cole G. Easson
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Physiology
Interaction Networks
Thinking
0302 clinical medicine
Cognition
Immune Physiology
Medicine and Health Sciences
Phylogeny
Innate Immune System
Multidisciplinary
Ecology
Gastrointestinal Microbiome
Biodiversity
Genomics
Sleep in non-human animals
Shannon Index
Medical Microbiology
Medicine
Cytokines
Sleep onset
medicine.symptom
Simpson Index
Research Article
Ecological Metrics
Firmicutes
Science
Immunology
Microbial Genomics
Biology
Microbiology
03 medical and health sciences
medicine
Genetics
Humans
Microbiome
Molecular Biology
Bacteria
Interleukin-6
Lachnospiraceae
Ecology and Environmental Sciences
Biology and Life Sciences
Actigraphy
Species Diversity
Molecular Development
biology.organism_classification
Sleep deprivation
030104 developmental biology
Immune System
Sleep
Physiological Processes
030217 neurology & neurosurgery
Developmental Biology
Zdroj: PLoS ONE
PLoS ONE, Vol 14, Iss 10, p e0222394 (2019)
ISSN: 1932-6203
Popis: The human gut microbiome can influence health through the brain-gut-microbiome axis. Growing evidence suggests that the gut microbiome can influence sleep quality. Previous studies that have examined sleep deprivation and the human gut microbiome have yielded conflicting results. A recent study found that sleep deprivation leads to changes in gut microbiome composition while a different study found that sleep deprivation does not lead to changes in gut microbiome. Accordingly, the relationship between sleep physiology and the gut microbiome remains unclear. To address this uncertainty, we used actigraphy to quantify sleep measures coupled with gut microbiome sampling to determine how the gut microbiome correlates with various measures of sleep physiology. We measured immune system biomarkers and carried out a neurobehavioral assessment as these variables might modify the relationship between sleep and gut microbiome composition. We found that total microbiome diversity was positively correlated with increased sleep efficiency and total sleep time, and was negatively correlated with wake after sleep onset. We found positive correlations between total microbiome diversity and interleukin-6, a cytokine previously noted for its effects on sleep. Analysis of microbiome composition revealed that within phyla richness of Bacteroidetes and Firmicutes were positively correlated with sleep efficiency, interleukin-6 concentrations and abstract thinking. Finally, we found that several taxa (Lachnospiraceae, Corynebacterium, and Blautia) were negatively correlated with sleep measures. Our findings initiate linkages between gut microbiome composition, sleep physiology, the immune system and cognition. They may lead to mechanisms to improve sleep through the manipulation of the gut microbiome.
Databáze: OpenAIRE
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