Isolation and characterization of the canine NKX2-5 gene
| Autor: | O'Leary C, Lavulo L, C. Hyun, Kim Jt |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Molecular Sequence Data
Biology Polymerase Chain Reaction Dogs stomatognathic system Food Animals Gene Order Animals Amino Acid Sequence Cardiac morphogenesis Gene DNA Primers Homeodomain Proteins Genetics Base Sequence Sequence Homology Amino Acid Genes Homeobox General Medicine respiratory system Nkx2 5 gene Molecular biology Mutation embryonic structures Homeobox Protein Nkx-2.5 cardiovascular system Female Animal Science and Zoology Sequence Alignment High homology Transcription Factors |
| Zdroj: | Journal of Animal Breeding and Genetics. 123:213-216 |
| ISSN: | 1439-0388 0931-2668 |
| DOI: | 10.1111/j.1439-0388.2006.00584.x |
| Popis: | We report the first isolation and characterization of the canine NKX2-5 gene. This canine homologue has high homology in genomic structure and functional domains to other NKX2-5 across a number of different species. Given the critical role of NKX2-5 in cardiac morphogenesis as seen in human and mouse studies of congenital heart defects, the availability of the canine NKX2-5 provides a good starting point for identifying mutations that may be responsible for certain forms of canine congenital heart defects. |
| Databáze: | OpenAIRE |
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