Clinical features and outcomes of bacteraemia due to OXA-48-like carbapenemase-producing Klebsiella pneumoniae in a tertiary hospital
Autor: | Ana Madueño, María del Mar Alonso Socas, María Antonia Miguel Gómez, Jonathan González-García, María Lecuona |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Male medicine.medical_specialty Klebsiella pneumoniae Urinary system 030106 microbiology Bacteremia beta-Lactamases Tertiary Care Centers 03 medical and health sciences Bacterial Proteins Internal medicine Antibiotic therapy medicine Humans Patient factors Aged Retrospective Studies biology business.industry Mortality rate Medical record High mortality Carbapenemase producing bacterial infections and mycoses biology.organism_classification Klebsiella Infections Female business |
Zdroj: | Enfermedades infecciosas y microbiologia clinica (English ed.). 36(8) |
ISSN: | 2529-993X |
Popis: | Introduction Limited therapeutic options and high mortality make the management of OXA-48-like carbapenemase-producing Klebsiella pneumoniae (KPOXA-48) bacteraemia complicated. The aim of the study was to describe the clinical characteristics of KPOXA-48 bacteraemia between October 2013 and December 2016. Material and methods The variables to analyse were retrospectively collected from medical records. Carbapenemase production was confirmed by phenotypic and molecular methods. Results A total of 38 patients with bacteraemia were included, mainly classified as hospital-acquired (n = 31). The majority of cases were secondary bacteraemia (n = 26), most commonly arising from the urinary tract (n = 11). All isolates presented a multidrug-resistant profile with the extended spectrum beta-lactamase CTX-M-15 and the carbapenemase OXA-48-like production. The crude mortality rate with adequate targeted antibiotic therapy was 0%, rising to 55% with inadequate treatment (p = 0.0015). Conclusions This study highlights the importance of identifying this resistance mechanism, the patient factors, type of bacteraemia and adequacy of antibiotic therapy in the outcome of bacteraemia. |
Databáze: | OpenAIRE |
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