High rate of left ventricular hypertrophy on screening echocardiography among adults living with HIV in Malawi
| Autor: | Risa M Hoffman, Florence Chibwana, Ben Allan Banda, Daniel Kahn, Khumbo Gama, Zachary P Boas, Mayamiko Chimombo, Chiulemu Kussen, Judith S Currier, Dan Namarika, Joep van Oosterhout, Sam Phiri, Agnes Moses, Jesse W Currier, Hitler Sigauke, Corrina Moucheraud, Tim Canan |
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| Rok vydání: | 2022 |
| Předmět: |
Adult
Male Malawi HIV Infections Global Health Cardiovascular Clinical Research Humans 2.1 Biological and endogenous factors Aetiology Prevention Evaluation of treatments and therapeutic interventions Hypertrophy Middle Aged Left Ventricular Cross-Sectional Studies Heart Disease Echocardiography RISK FACTORS 6.1 Pharmaceuticals Hypertension HIV/AIDS Hypertrophy Left Ventricular Female Cardiology and Cardiovascular Medicine |
| Zdroj: | Open heart, vol 9, iss 1 |
| ISSN: | 2053-3624 |
| Popis: | BackgroundThere are limited data on structural heart disease among people living with HIV in southern Africa, where the success of antiretroviral therapy (ART) has drastically improved life expectancy and where risk factors for cardiovascular disease are prevalent.MethodsWe performed a cross-sectional study of screening echocardiography among adults (≥18 years) with HIV in Malawi presenting for routine ART care. We used univariable and multivariable logistic regression to evaluate correlates of abnormal echocardiogram.ResultsA total of 202 individuals were enrolled with a median age of 45 years (IQR 39–52); 52% were female, and 27.7% were on antihypertensive medication. The most common clinically significant abnormality was left ventricular hypertrophy (LVH) (12.9%, n=26), and other serious structural heart lesions were rare (ConclusionsLVH was common in this population of adults on ART presenting for routine care and was associated with elevated blood pressure. Further research is needed to characterise the relationship between chronic hypertension, LVH and downstream consequences, such as diastolic dysfunction and heart failure in people living with HIV. |
| Databáze: | OpenAIRE |
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