Melanocortin 1 Receptor Agonists Reduce Proteinuria
Autor: | Anna Granqvist, Martin Johansson, Anna-Lena Berg, Margret Arnadottir, Bergur V. Stefánsson, Jenny Nyström, Börje Haraldsson, Kerstin Ebefors, Annika Lindskog |
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Rok vydání: | 2010 |
Předmět: |
Adult
Male medicine.medical_specialty Biology urologic and male genital diseases Glomerulonephritis Membranous Podocyte Heymann Nephritis Adrenocorticotropic Hormone Melanocortin receptor Membranous nephropathy Internal medicine medicine Animals Humans Aged Podocytes urogenital system Endothelial Cells Glomerulonephritis General Medicine Middle Aged medicine.disease Hormones Rats Disease Models Animal Proteinuria Basic Research medicine.anatomical_structure Endocrinology Nephrology Mesangial Cells Female Synaptopodin Urothelium Melanocortin Receptor Melanocortin Type 1 Nephrotic syndrome |
Zdroj: | Journal of the American Society of Nephrology. 21:1290-1298 |
ISSN: | 1046-6673 |
Popis: | Membranous nephropathy is one of the most common causes of nephrotic syndrome in adults. Recent reports suggest that treatment with adrenocorticotropic hormone (ACTH) reduces proteinuria, but the mechanism of action is unknown. Here, we identified gene expression of the melanocortin receptor MC1R in podocytes, glomerular endothelial cells, mesangial cells, and tubular epithelial cells. Podocytes expressed most MC1R protein, which colocalized with synaptopodin but not with an endothelial-specific lectin. We treated rats with passive Heymann nephritis (PHN) with MS05, a specific MC1R agonist, which significantly reduced proteinuria compared with untreated PHN rats (P < 0.01). Furthermore, treatment with MC1R agonists improved podocyte morphology and reduced oxidative stress. In summary, podocytes express MC1R, and MC1R agonism reduces proteinuria, improves glomerular morphology, and reduces oxidative stress in nephrotic rats with PHN. These data may explain the proteinuria-reducing effects of ACTH observed in patients with membranous nephropathy, and MC1R agonists may provide a new therapeutic option for these patients. |
Databáze: | OpenAIRE |
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