Urinary phthalate concentrations and mortality risk: A population-based study

Autor: Anika Beyer, Paula Schorgg, Nena Karavasiloglou, Sneha Sarwar, Sabine Rohrmann, Till Bärnighausen, Aedin Cassidy, Lisa Connolly, Tilman Kühn
Přispěvatelé: University of Zurich, Kühn, Tilman
Rok vydání: 2022
Předmět:
Zdroj: Beyer, A, Schorgg, P, Karavasiloglou, N, Sarwar, S, Rohrmann, S, Bärnighausen, T, Cassidy, A, Connolly, L & Kühn, T 2022, ' Urinary phthalate concentrations and mortality risk: A population-based study ', Environmental Research, vol. 214, no. Part 2, 113927 . https://doi.org/10.1016/j.envres.2022.113927
ISSN: 1096-0953
DOI: 10.1016/j.envres.2022.113927
Popis: Phthalates are widely used as plasticizers. Laboratory-based mechanistic and epidemiological studies suggest that phthalates are detrimental to human health. Here, we present prospective analyses on phthalate exposure and all-cause, as well as cause-specific, mortality from the National Health and Nutrition Examination Survey (NHANES), a population-based cohort. Between 1999 and 2018, urinary concentrations of 12 phthalate metabolites were measured by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry in spot urine samples of 10,881 adults aged 40-85 years, of which 2382 died over a median duration of 8.9 years after sample provision. Multivariable Cox regression analyses adjusted for a wide range of lifestyle factors and comorbidities showed that higher concentrations of mono-benzyl phthalate (MBzP) and Mono-n-butyl phthalate (MnBP) were associated with increased mortality. The hazard ratios for participants in the highest quartiles of MBzP and MnBP concentrations were at 1.27 [95% confidence interval: 1.08, 1.49; p linear trend = 0.002] and 1.35 [1.13, 1.62; p linear trend = 0.005). These findings reinforce the need for monitoring of phthalate exposure in relation to health outcomes.
Databáze: OpenAIRE
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