Short-term effects of treatment with simvastatin on testicular function in patients with heterozygous familial hypercholesterolaemia
| Autor: | Henrik Lambrecht Lund, E. Haug, A. Tollefsrud, Hallgeir Rui, J Norseth, L. Ose, L. Viksmoen, K. Purvis |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Heterozygote Simvastatin endocrine system medicine.medical_specialty Testicle Hyperlipoproteinemia Type II chemistry.chemical_compound High-density lipoprotein Internal medicine Testis medicine Humans Single-Blind Method Pharmacology (medical) Lovastatin Testosterone Pharmacology Cholesterol business.industry Anticholesteremic Agents Fructose General Medicine Middle Aged Spermatozoa Sperm Hormones Prolactin medicine.anatomical_structure Endocrinology chemistry lipids (amino acids peptides and proteins) business medicine.drug |
| Zdroj: | European Journal of Clinical Pharmacology. 42:61-64 |
| ISSN: | 1432-1041 0031-6970 |
| Popis: | The effects of simvastatin 40 mg per day for 14 weeks on the pituitary-testis axis of 19 men with familial hypercholesterolaemia have been examined in a single-blind study. Simvastatin significantly reduced serum low density lipoprotein (LDL) cholesterol and triglycerides by 45% and 30%, respectively, and significantly increased high density lipoprotein (HDL) cholesterol by 15%. The alterations, which were stable 4 weeks after the start of treatment, were not associated with any significant change in sperm quality, the seminal plasma concentrations of various sex gland products (prostate-specific acid phosphatase, polyamines, citrate, fructose, alpha-glucosidase), or the serum concentrations of cortisol, testosterone, LH, FSH, or prolactin. It is concluded that a short-term reduction in circulating LDL-cholesterol has no marked effect on testicular function or sperm quality. |
| Databáze: | OpenAIRE |
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