Whole-exome sequencing study reveals common copy number variants in protocadherin genes associated with childhood obesity in Koreans
| Autor: | Han S, Mi Yeong Hwang, Song J, Jang Hb, Moon S, Park Si, Hwang Jy, Kim Bj, Hyo-Pyo Lee, Kim Yj |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Pediatric Obesity animal structures Adolescent DNA Copy Number Variations Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Protocadherin 030209 endocrinology & metabolism Biology Childhood obesity 03 medical and health sciences 0302 clinical medicine Asian People Republic of Korea Exome Sequencing medicine Humans Exome Genetic Predisposition to Disease Copy-number variation Child Gene Exome sequencing Genetics Nutrition and Dietetics Reproducibility of Results medicine.disease Cadherins Obesity 030104 developmental biology Female Body mass index Genome-Wide Association Study |
| Zdroj: | International journal of obesity (2005). 41(4) |
| ISSN: | 1476-5497 |
| Popis: | Recently, the prevalence of childhood obesity has significantly increased in industrialized countries, including Korea, and now controlling obesity is becoming an economic burden. However, knowledge of the risk factors associated with obesity is still limited. In this study, we aimed to discover additional obesity-associated loci in children. To achieve this, we conducted an exome-wide association analysis of copy number variation (CNV) using whole-exome sequencing (WES) data from a total of 102 cases and 86 controls. We newly identified a CNV locus that overlapped two protocadherin genes, PCDHB7 and PCDHB8, which are brain function-related genes (P-value=6.40 × 10 |
| Databáze: | OpenAIRE |
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