Response of rat jejunum to changes in sodium and volume balance
| Autor: | N. R. Levens |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
medicine.medical_specialty Captopril Physiology medicine.drug_class Sodium chemistry.chemical_element Absorption (skin) Nephrectomy Plasma renin activity Jejunum chemistry.chemical_compound Enalapril Physiology (medical) Internal medicine Renin Renin–angiotensin system medicine Animals Aldosterone Blood Volume Hepatology Gastroenterology Adrenalectomy Rats Inbred Strains Serum Albumin Bovine Small intestine Diet Rats Endocrinology medicine.anatomical_structure Intestinal Absorption chemistry Mineralocorticoid Extracellular Space |
| Zdroj: | American Journal of Physiology-Gastrointestinal and Liver Physiology. 251:G413-G420 |
| ISSN: | 1522-1547 0193-1857 |
| DOI: | 10.1152/ajpgi.1986.251.3.g413 |
| Popis: | Initial studies determined whether a renal factor facilitates decreased jejunal absorption following volume expansion of the anesthetized rat. Volume expansion (VE) decreased jejunal absorption to the same extent in both normal and nephrectomized animals. Furthermore, VE of a donor animal failed to alter jejunal absorption in a recipient following cross circulation. Thus, a hormonal factor is not implicated in the jejunal response to VE. Additional experiments demonstrated that rats ingesting a high-Na diet exhibited levels of jejunal absorption lower than animals fed a normal-Na diet. High-Na animals were not volume expanded. Plasma aldosterone concentrations and plasma renin activity were reduced in high-Na animals. Bilateral adrenalectomy-nephrectomy inhibited jejunal absorption. However, neither bilateral adrenalectomy nor bilateral nephrectomy alone inhibited jejunal absorption. Furthermore, inhibition of angiotensin formation in adrenalectomized animals failed to alter jejunal absorption. Decreased jejunal absorption in high-Na animals is not due to volume expansion or to inhibition of the renin-angiotensin-aldosterone axis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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