Microwave-assisted organic synthesis: scale-up of palladium-catalyzed aminations using single-mode and multi-mode microwave equipment

Autor:	Kristof T. J. Loones, Gaston Stanislas Marcell Diels, Geert Rombouts, Steven Hostyn, Bert U. W. Maes
Rok vydání:	2005
Předmět:	Chemistry business.industry Organic Chemistry Single-mode optical fiber chemistry.chemical_element Buchwald–Hartwig amination Biochemistry Catalysis chemistry.chemical_compound Drug Discovery SCALE-UP Organic chemistry Organic synthesis Process engineering business Amination Microwave Palladium
Zdroj:	Tetrahedron
ISSN:	0040-4020
Popis:	Batch wise scale-up of Buchwald–Hartwig aminations under microwave irradiation has been investigated for the first time. Multi-mode (microSYNTH and MARS) (several vessels irradiated in parallel per batch) as well as single-mode (Discover) (one vessel irradiated per batch) platforms can be successfully used for this purpose with trifluoromethylbenzene (benzotrifluoride: BTF) as amination solvent. The obtained yields indicate a direct scalability in BTF for all the studied aminations. The Voyager equipment (based on a Discover platform) is the most convenient system since it allows an automatic continuous batch wise production without the necessity to manually load and unload reaction vessels.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4027a2d97cf584713a2833c9bf0c4f8d https://doi.org/10.1016/j.tet.2005.07.105 Zobrazit plný text záznamu Full Text from ScienceDirect