Klotho as a biomarker of subclinical atherosclerosis in patients with moderate to severe chronic kidney disease
| Autor: | Ernesto Martín-Núñez, Nayra Pérez-Delgado, Javier Donate-Correa, Carmen Mora-Fernández, Carla Ferri, Juan F. Navarro-González, Ainhoa González-Luis |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Science Population Gene Expression Renal function Disease Predictive markers urologic and male genital diseases Carotid Intima-Media Thickness Severity of Illness Index Gastroenterology Article Prognostic markers Risk Factors Internal medicine medicine Humans Ankle Brachial Index Renal Insufficiency Chronic education Klotho Proteins Klotho Aged Glucuronidase Subclinical infection education.field_of_study Multidisciplinary business.industry Area under the curve Diagnostic markers Middle Aged Atherosclerosis medicine.disease female genital diseases and pregnancy complications Cross-Sectional Studies ROC Curve Cardiovascular Diseases Spain Nephrology Medicine Biomarker (medicine) Female Transcriptome business Biomarkers Kidney disease |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Chronic kidney disease (CKD) has been associated with a higher risk of cardiovascular disease (CVD). CKD patients present a decrease in the levels of the protein Klotho that accompanies the decrease in kidney function. This protein has been related to protective effects against CVD. However, it is unclear whether circulating Klotho, and its expression in peripheral blood cells (PBCs) are also associated with subclinical atherosclerosis in CKD. The present study aimed to study the relationship between Klotho and subclinical atherosclerosis in a population of patients with moderate to severe CKD. We determined the serum levels and gene expression in PBCs levels of Klotho and three inflammatory cytokines in 103 patients with CKD and investigated their relationship with two surrogate markers of subclinical atherosclerotis: ankle-brachial index (ABI) and carotid intima-media thickness (CIMT). Patients with subclinical atherosclerosis presented lower serum and PBCs expression levels of Klotho. Both variables were associated with the presence of subclinical atherosclerosis, being directly related with ABI and inversely with CIMT (P 2 = 0.511, P 2 = 0.445, P P = 0.002) and 0.231 (P = 0.025), respectively]. Receiver operating characteristic analysis pointed to the utility of serum Klotho (area under the curve [AUC]: 0.817, 95% CI: 0.736–0.898, P P |
| Databáze: | OpenAIRE |
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