Aryl hydrocarbon receptor controls murine mast cell homeostasis
| Autor: | Ying Ming Tsai, Beverly Plunkett, Peisong Gao, Hsiao Chun Tseng, Becky M. Vonakis, Hirokazu Kawasaki, Shau Ku Huang, Hui Wen Chang, Shih Chang Hsu, Yufeng Zhou, Hui Ying Tung, Chih Hsing Hung |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Mast cell differentiation
medicine.medical_treatment Immunology Carbazoles Apoptosis Protein Tyrosine Phosphatase Non-Receptor Type 11 Immunoglobulin E Biochemistry Cell Degranulation Mice Phagocytes Granulocytes and Myelopoiesis medicine Animals Homeostasis Humans Mast Cells Antigens Cells Cultured biology Degranulation Cell Biology Hematology respiratory system Mast cell Aryl hydrocarbon receptor Cell biology respiratory tract diseases Mitochondria Cytokine medicine.anatomical_structure Receptors Aryl Hydrocarbon biology.protein Calcium Mast cell homeostasis Signal transduction Reactive Oxygen Species Oxidation-Reduction Gene Deletion Signal Transduction |
| Zdroj: | Blood. 121(16) |
| ISSN: | 1528-0020 |
| Popis: | We propose that the aryl hydrocarbon receptor (AhR), a unique chemical sensor, is critical in controlling mast cell differentiation, growth, and function in vitro and in vivo. In antigen-stimulated mast cells, exposure to AhR ligands resulted in a calcium- and reactive oxygen species (ROS)-dependent increase of reversible oxidation in and reduced activity of SHP-2 phosphatase, leading to enhanced mast cell signaling, degranulation, and mediator and cytokine release, as well as the in vivo anaphylactic response. Surprisingly, significant mast cell deficiency was noted in AhR-null mice due to defective calcium signaling and mitochondrial function, concomitant with reduced expression of c-kit and cytosolic STAT proteins, as well as enhanced intracellular ROS and apoptosis. Consequently, AhR-null mast cells responded poorly to stimulation, demonstrating a critical role of AhR signaling in maintaining mast cell homeostasis. |
| Databáze: | OpenAIRE |
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