Immunological Involvement in the Pathogenesis of Pristane-Induced Arthritis
| Autor: | Christopher J. Elson, C. E. Hinton, A. E. Bedwell |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
Immunology Congenic Arthritis Mice Inbred Strains Pathogenesis Mice chemistry.chemical_compound Immune system Pristane induced arthritis medicine Animals Heavy chain biology Terpenes business.industry Pristane General Medicine medicine.disease chemistry biology.protein Antibody business Spleen Whole-Body Irradiation |
| Zdroj: | Scandinavian Journal of Immunology. 25:393-398 |
| ISSN: | 1365-3083 0300-9475 |
| DOI: | 10.1111/j.1365-3083.1987.tb02205.x |
| Popis: | Evidence is presented that the development of arthritis induced in mice by 2,6,10,14-tetra-methylpentadecane (pristane) involves the immune response. Mice irradiated (500 rad) before injection of pristane failed to develop arthritis. By contrast, irradiated mice given lymphoid cells from normal donors and challenged with pristane developed arthritis. Other experiments showed that lymphoid cells from irradiated mice given pristane suppressed the development of arthritis in recipients challenged with pristane. Finally, the incidence of arthritis was significantly higher in CBA/Igb mice given pristane than in the allotypic congenic strain CBA/H, suggesting that a gene linked to the heavy chain immunoglobulin locus controls the development of arthritis. |
| Databáze: | OpenAIRE |
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